Poster De Conférence Année : 2017

Occupational Status Moderates The Association Between Depressive Symptoms And Predicted 10-Year Risk Of Coronary Heart Disease In Participants Of The French Constances Cohort

Jean‐philippe Empana
Sébastien Czernichow
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Cèdric Lemogne
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Hermann Nabi

Résumé

Background: A growing body of evidence suggests that the association of psychological variables with cardiometabolic risk might depend upon socioeconomic status. Here, we examined the moderating effect of occupational status (OS) on the association between depressive symptoms and predicted 10-year risk of coronary heart disease (CHD) in working participants from the population-based CONSTANCES cohort. Methods: A total of 34,059 participants (15,736 men, mean age: 44.0 ± 10.4 years) without a history of cardiovascular disease completed the Center of Epidemiologic Studies Depression scale (CES-D). The presence of depressive symptoms was defined as a CES-D score ≥ 19. The 10-year French CHD risk equation model included age, gender, age x gender interaction, current smoking status, diabetes status, systolic blood pressure, total and HDL cholesterol (Empana JP et al. Predicting CHD risk in France: a pooled analysis of the D.E.S.I.R., Three City, PRIME, and SU.VI.MAX studies. Eur J Cardiovasc Prev Rehabil. 2011;18:175-85). OS was categorized in 3 classes: (1) high (e.g., managers); (2) medium (e.g., clerks or first-line supervisors); (3) low (e.g., blue collar workers). Associations between depressive symptoms and CHD risk were estimated with coefficients (b) and 95% confidence intervals (CI) computed in linear regressions. Results: Overall, the predicted 10-year risk of coronary heart disease was 17.1% in men and 1.8 % in women. In men, there was an interaction between depressive symptoms and OS (p=0.048). Significant associations with depressive symptoms were found among participants of medium OS [b (95% CI): 1.45 (0.33;2.57)] and low OS [b (95% CI): 3.05 (1.15;4.95)] but not in participants of high OS [b (95% CI): 0.33 (-0.09;1.61)]. In women, the interaction between depressive symptoms and OS was not significant (p=0.091). Sensitivity analyses using the CESD-D score as a continuous variable yielded similar results. Conclusions: The association between depressive symptoms and predicted 10-year risk of CHD could depend upon OS among men. A lower risk of CHD in women at this mean age could explain the lack of such a moderating effect. This study suggests that OS should be considered when evaluating the risk of CHD in depressed individuals, at least in men.

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hal-04569928 , version 1 (25-11-2025)

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  • HAL Id : hal-04569928 , version 1

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Emmanuel Wiernik, Jean‐philippe Empana, Sébastien Czernichow, Cèdric Lemogne, Hermann Nabi, et al.. Occupational Status Moderates The Association Between Depressive Symptoms And Predicted 10-Year Risk Of Coronary Heart Disease In Participants Of The French Constances Cohort. 75th Annual Meeting of the American Psychosomatic Societ, Mar 2017, Séville, France. ⟨hal-04569928⟩
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