Ryanodine Receptors - Archive ouverte HAL Accéder directement au contenu
Chapitre D'ouvrage Année : 2023

Ryanodine Receptors

Résumé

The ryanodine receptor (RyR) is the largest known channel, named for specifically binding the alkaloid ryanodine. It is a homotetramer with high conductance for monovalent and divalent cations. Although not very Ca2+ selective, RyRs function as a Ca2+ release channel from the sarco/endoplasmic reticulum, amplifying the initial Ca2+ signaling from the sarcolemmal L-type Ca2+ channels for contraction or secretion. There are three RyR subtypes: RyR1 in skeletal muscle, RyR2 mainly in cardiac muscle and brain, and RyR3 that is more ubiquitous. RyR crystallography structure shows a bulky cytosolic N-terminal portion and a transmembrane portion. Its natural activator is the cytosolic Ca2+, but it is also sensitive to the luminal Ca2+. The RyR interacts with multiple proteins in both sides of the sarco/endoplasmic reticulum, which modify its function. RyRs also suffer posttranslational modifications, which for most of them increase their activity. Alteration of regulatory proteins or in posttranslational status is associated with diseases, such as heart failure. Today, more than 300 RyR mutations have been linked to different genetic diseases, such as myopathies for RyR1, cardiac diseases for RyR2 and Alzheimer’s disease for RyR3. Because RyRs are linked to both genetic and acquired diseases, current research is seeking agents targeting RyRs.
Fichier non déposé

Dates et versions

hal-04566782 , version 1 (02-05-2024)

Identifiants

Citer

Jean-Pierre Benitah, Laetitia Pereira, Liheng Yin, Jean-Jacques Mercadier, Marine Gandon-Renard, et al.. Ryanodine Receptors. Textbook of Ion Channels Volume II, 1, CRC Press, pp.413-430, 2023, 9781003096276. ⟨10.1201/9781003096276-27⟩. ⟨hal-04566782⟩
7 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More