Previous studies have investigated the relationship between quality of life (QoL) and video game use. However, it remains to clarify the nature of these relationships. This longitudinal study investigated the links between two gaming-related variables – objective playtime indicators and self-reported gaming disorder (GD) symptoms – and QoL, while accounting for gamers’ motivational background. We longitudinally surveyed intensive gamers (final sample: NT1 = 4772, NT2 = 2021, NT3 = 1128), assessing gaming motives, GD symptoms, psychological correlates (impulsivity, personality, self-esteem), and health-related information (quality of life, anxiety and depression), while collecting objective behavioral data. Cluster analyses and random intercept cross-lagged panel models were performed to identify subgroups and investigate gaming-related variables-QoL relationships. Cluster analysis identified two non-problematic (competitive and recreational) and one vulnerable (escapers) gamer subtypes. Random intercept cross-lagged panel models only showed between-person effects regarding the GD symptoms-QoL relationship. No effects were found concerning the objective playtime-QoL relationship. Results did not differ across motivational profiles. In line with previous research, our data support the common causes hypothesis, which posits that GD symptoms-impaired QoL association results from shared risk factors, such as specific personality traits and impulsivity. Clinical assessment and prevention efforts should focus on these common causes and on gamers’ motivational background. Intensive involvement may not be in itself problematic.