Catalytic Synthesis of β‐(Hetero)arylethylamines: Modern Strategies and Advances - Archive ouverte HAL
Article Dans Une Revue Angewandte Chemie International Edition Année : 2023

Catalytic Synthesis of β‐(Hetero)arylethylamines: Modern Strategies and Advances

Résumé

β-(Hetero)arylethylamines appear in a myriad of pharmaceuticals due to their broad spectrum of biological properties, making them prime candidates for drug discovery. Conventional methods for their preparation often require engineered substrates that limit the flexibility of the synthetic routes and the diversity of compounds that can be accessed. Consequently, methods that provide rapid and versatile access to those scaffolds remain limited. To overcome these challenges, synthetic chemists have designed innovative and modular strategies to access the β-(hetero)arylethylamine motif, paving the way for their more extensive use in future pharmaceuticals. This review outlines recent progresses in the synthesis of (hetero)arylethylamines and emphasizes how these innovations have enabled new levels of molecular complexity, selectivity, and practicality.

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Catalyse
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hal-04564878 , version 1 (30-04-2024)

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Valentyn Pozhydaiev, Cyprien Muller, Joseph Moran, David Lebœuf. Catalytic Synthesis of β‐(Hetero)arylethylamines: Modern Strategies and Advances. Angewandte Chemie International Edition, 2023, 62 (41), ⟨10.1002/anie.202309289⟩. ⟨hal-04564878⟩
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