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Article Dans Une Revue JACS Au Année : 2024

Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes

Angela Marseglia
Suvarn Kulkarni
Franck Fieschi
Biao Yu

Résumé

The evaluation of Bacteroides vulgatus mpk (BVMPK) lipopolysaccharide (LPS) recognition by DC-SIGN, a key lectin in mediating immune homeostasis, has been here performed. A fine chemical dissection of BVMPK LPS components, attained by synthetic chemistry combined to spectroscopic, biophysical, and computational techniques, allowed to finely map the LPS epitopes recognized by DC-SIGN. Our findings reveal BVMPK's role in immune modulation via DC-SIGN, targeting both the LPS O-antigen and the core oligosaccharide. Furthermore, when framed within medical chemistry or drug design, our results could lead to the development of tailored molecules to benefit the hosts dealing with inflammatory diseases.

Dates et versions

hal-04556770 , version 1 (23-04-2024)

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Citer

Ferran Nieto-Fabregat, Qian Zhu, Corinne Vivès, Yunqin Zhang, Angela Marseglia, et al.. Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes. JACS Au, 2024, 4 (2), pp.697-712. ⟨10.1021/jacsau.3c00748⟩. ⟨hal-04556770⟩
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