Health benefits of innovated Curcuma longa extract
Résumé
Used traditionally for thousands of years in Asia, Curcuma longa is now of growing interest for its various health benefits in conventional medicine, cosmetology and nutraceutical. Indeed, turmeric’s compounds, particularly curcuminoids, have already been shown to be active in anti-inflammatory, antioxidant, antibacterial, anticancer and hepato-protective effects. Their interest in the support of chronic pathologies is illustrated in several clinical trials. In addition, emerging studies show the biotransformation of turmeric improves health effects. It is with this objective that a new ingredient will be developed. The purpose of this work is the demonstration of
increased bioactivities of an extract of Curcuma longa. Indeed, the final product will be distinguished by a plant totum obtained after an innovative biotechnology process. After the characterization of turmeric’s bio compounds, health effects are demonstrated according to several study models such as an in vitro cellular model of intestinal
barrier including Caco-2, HT29-MTX and U937 cells. The antioxidant mechanisms are studied according to 4 different tests: FRAP, DPPH, ABTS and Cuprac. Impact of digestion is also studied on the final product according to an in vitro model mimicking the gastrointestinal digestion. Finally, the health potential of this nutraceutical will
be enhanced by optimizing the biotransformation process of turmeric.
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers produits par l'(les) auteur(s) |
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