In the context of a more respectful use of pesticides in the environment, lipopeptides produced by Bacillus sp. are very promising molecules. This work presents the main results obtained within two scientific projects. The first projects, the France-Wallonia-Flanders BIOPROD and BIOPROTECT Interreg project bring together a consortium of Universities, agricultural technical institutes and a company from the North of France and from Belgium to remove the constraints related to the industrial production of these new biopesticides and then the study of their efficacy in greenhouse and field. The second one, the AGRIBIOPOM project studied the potential of these molecules to control apple scab in organic farming. The actions conducted in these projects are: The optimisation of the production and the purification of the molecules [1]; The study of the biodegradability and toxicity of the molecules on different models to demonstrate the positive impact of these new biopesticides compared to chemicals curently used in agriculture; The evaluation of the potential of the lipopeptides for the protection of important crops against phytopathogenic fungi. The presentation of this work will be mainly focused on the results obtained on the efficacy of the lipopeptides against different pathosystems, such as: Zymosepteria tritici-wheat [2]; Venturia inaequalis-apple; Bremia lactucae-lettuce [3]; Phytophthora infestans-potatoes [4]; Fusarium-ornamental plants [5].