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Article Dans Une Revue Annals of Surgery Année : 2023

Novel Benchmark Values for Open Major Anatomic Liver Resection in Non-cirrhotic Patients

Richard Sousa da Silva (1) , Eva Breuer (1) , Sadhana Shankar (2) , Shoji Kawakatsu (3) , Wacław Hołówko (4) , João Santos Coelho (5) , Heithem Jeddou (6) , Teiichi Sugiura (7) , Mohammed Ghallab (8) , Doris da Silva (9) , Genki Watanabe (10) , Florin Botea (11) , Nozomu Sakai (12) , Pietro Addeo (13, 10) , Stylianos Tzedakis (14, 15, 16) , Fabian Bartsch (17) , Kaja Balcer (18) , Chetana Lim (19) , Fabien Werey (20) , Victor Lopez-Lopez (21) , Luciana Peralta Montero (22) , Rodrigo Sanchez Claria (22) , Jennifer Leiting (23) , Neeta Vachharajani (24) , Eve Hopping (25) , Orlando Torres (26) , Satoshi Hirano (27) , Daan Andel (28) , Jeroen Hagendoorn (28) , Alicja Psica (29) , Matteo Ravaioli (30) , Keun Soon Ahn (31) , Tim Reese (32) , Leonardo Montes (33) , Ganesh Gunasekaran (34) , Cándido Alcázar (35) , Jin Hong Lim (36) , Muhammad Haroon (37) , Qian Lu (38) , Antonio Castaldi (39) , Tatsuya Orimo (27) , Beat Moeckli (40) , Teresa Abadía (41) , Luis Ruffolo (42) , Josefina Dib Hasan (43) , Francesca Ratti (44) , Emmanuele Kauffmann (45) , Roeland de Wilde (46) , Wojciech Polak (46) , Ugo Boggi (45) , Luca Aldrighetti (44) , Lucas Mccormack (43) , Roberto Hernandez-Alejandro (42) , Alejandro Serrablo (41) , Christian Toso (47) , Akinobu Taketomi (27) , Jean Gugenheim (48) , Jiahong Dong (38) , Faisal Hanif (37) , Joon Seong Park (36) , José Ramia (35) , Myron Schwartz (34) , Diego Ramisch (49) , Michelle de Oliveira (1) , Karl Oldhafer (32) , Koo Jeong Kang (31) , Matteo Cescon (50) , Peter Lodge (51) , Inne Rinkes (28) , Takehiro Noji (52) , John-Edwin Thomson (25) , Su Kah Goh (25) , William Chapman (53) , Sean Cleary (54) , Juan Pekolj (22) , Jean-Marc Regimbeau (55) , Olivier Scatton (56) , Stéphanie Truant (18) , Hauke Lang (57) , David Fuks (16) , Philippe Bachellier (58) , Masayuki Ohtsuka (12) , Irinel Popescu (11) , Kiyoshi Hasegawa (10) , Mickaël Lesurtel (9) , René Adam (59) , Daniel Cherqui (59) , Katsuhiko Uesaka (7) , Karim Boudjema (60) , Hugo Pinto-Marques (5) , Michał Grąt (4) , Henrik Petrowsky (1) , Tomoki Ebata (61) , Andreas Prachalias (2) , Ricardo Robles-Campos (62) , Pierre-Alain Clavien (1)
1 University hospital of Zurich [Zurich]
2 KCH - King's College Hospital
3 Nagoya City University [Nagoya, Japan]
4 Medical University of Warsaw - Poland
5 Centro Hospitalar Universitário Lisboa Central
6 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
7 Shizuoka Cancer Center Hospital
8 CHB - Centre Hépato-Biliaire [Hôpital Paul Brousse]
9 Hôpital Beaujon [AP-HP]
10 UTokyo - The University of Tokyo
11 Fundeni Clinical Institute = Institutul Clinic Fundeni [Bucarest, Roumanie]
12 Chiba University Hospital
13 Pôle des Pathologies Digestives Hépatiques et Transplantation [Hôpital Hautepierre-Strasbourg]
14 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
15 HeKA - Health data- and model- driven Knowledge Acquisition
16 Hôpital Cochin [AP-HP]
17 LEM - Lille économie management - UMR 9221
18 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
19 CHU Pitié-Salpêtrière [AP-HP]
20 Chirurgie digestive [CHU Amiens]
21 Instituto Tecnológico de Tijuana = Tijuana Institute of Technology [Tijuana]
22 Hospital Italiano de Buenos Aires
23 Mayo Clinic
24 Washington University School of Medicine [Saint Louis, MO]
25 Royal Adelaide Hospital [Adelaide Australia]
26 Presidente Dutra Hospital [São Luís]
27 Hokkaido University Hospital [Sapporo]
28 UMCU - University Medical Center [Utrecht]
29 St James's University Hospital
30 IRCCS - Istituti di Ricovero e Cura a Carattere Scientifico
31 Keimyung University
32 Semmelweis University of Medicine [Budapest]
33 University Hospital [Buenos Aires]
34 MSSM - Icahn School of Medicine at Mount Sinai [New York]
35 General University Hospital of Alicante
36 Yonsei University
37 Bahria International Hospital Orchard [Lahore]
38 THU - Tsinghua University [Beijing]
39 CHU Nice [Cimiez]
40 HUG - Hôpitaux Universitaires de Genève
41 Hospital Universitario Miguel Servet
42 University of Rochester [USA]
43 Hospital Alemán [Buenos Aires]
44 IRCCS Ospedale San Raffaele [Milan, Italy]
45 University of Pisa - Università di Pisa
46 Erasmus MC - Erasmus University Medical Center [Rotterdam]
47 HUG - Hôpitaux universitaires de Genève = University Hospitals of Geneva
48 CHU - Hôpital Cimiez [Nice]
49 Favaloro Foundation
50 AOUB - IRCCS Azienda Ospedaliero-Universitaria di Bologna
51 Leeds Teaching Hospitals NHS Trust
52 Hokkaido University of Science
53 WUSTL - Washington University in Saint Louis
54 Mayo Clinic [Rochester]
55 CHU Amiens-Picardie
56 PASS-CYPS - Cytométrie Pitié-Salpêtrière
57 University Medical Center [Mainz]
58 UNISTRA - Université de Strasbourg
59 Hôpital Paul Brousse
60 Hôpital Sud [CHU Rennes]
61 Nagoya University
62 IMIB - Instituto Murciano de Investigación Biosanitaria Pascual Parrilla
Jennifer Leiting
  • Fonction : Auteur
Jin Hong Lim
  • Fonction : Auteur
Jean-Marc Regimbeau
René Adam
  • Fonction : Auteur
Tomoki Ebata
  • Fonction : Auteur

Résumé

Objective: This study aims at establishing benchmark values for best achievable outcomes following open major anatomic hepatectomy for liver tumors of all dignities. Background: Outcomes after open major hepatectomies vary widely lacking reference values for comparisons among centers, indications, types of resections, and minimally invasive procedures. Methods: A standard benchmark methodology was used covering consecutive patients, who underwent open major anatomic hepatectomy from 44 high-volume liver centers from 5 continents over a 5-year period (2016–2020). Benchmark cases were low-risk non-cirrhotic patients without significant comorbidities treated in high-volume centers (≥30 major liver resections/year). Benchmark values were set at the 75th percentile of median values of all centers. Minimum follow-up period was 1 year in each patient. Results: Of 8044 patients, 2908 (36%) qualified as benchmark (low-risk) cases. Benchmark cutoffs for all indications include R0 resection ≥78%; liver failure (grade B/C) ≤10%; bile leak (grade B/C) ≤18%; complications ≥grade 3 and CCI ® ≤46% and ≤9 at 3 months, respectively. Benchmark values differed significantly between malignant and benign conditions so that reference values must be adjusted accordingly. Extended right hepatectomy (H1, 4-8 or H4-8) disclosed a higher cutoff for liver failure, while extended left (H1-5,8 or H2-5,8) were associated with higher cutoffs for bile leaks, but had superior oncologic outcomes, when compared to formal left hepatectomy (H1-4 or H2-4). The minimal follow-up for a conclusive outcome evaluation following open anatomic major resection must be 3 months. Conclusion: These new benchmark cutoffs for open major hepatectomy provide a powerful tool to convincingly evaluate other approaches including parenchymal-sparing procedures, laparoscopic/robotic approaches, and alternative treatments, such as ablation therapy, irradiation, or novel chemotherapy regimens.
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Dates et versions

hal-04544070 , version 1 (12-04-2024)

Identifiants

Citer

Richard Sousa da Silva, Eva Breuer, Sadhana Shankar, Shoji Kawakatsu, Wacław Hołówko, et al.. Novel Benchmark Values for Open Major Anatomic Liver Resection in Non-cirrhotic Patients. Annals of Surgery, 2023, 278 (5), pp.748-755. ⟨10.1097/SLA.0000000000006012⟩. ⟨hal-04544070⟩
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