Hypercaloric low-carbohydrate high-fat diet protects against the development of nonalcoholic fatty liver disease in obese mice in contrast to isocaloric Western diet. - Archive ouverte HAL Access content directly
Journal Articles Frontiers in Nutrition Year : 2024

Hypercaloric low-carbohydrate high-fat diet protects against the development of nonalcoholic fatty liver disease in obese mice in contrast to isocaloric Western diet.

Abstract

Obesity and metabolic complications, such as type 2 diabetes and nonalcoholic fatty liver disease (NAFLD), are one of the greatest public health challenges of the 21st century. The major role of high sugar and carbohydrate consumption rather than caloric intake in obesity and NAFLD pathophysiology remains a subject of debate. A low-carbohydrate but high-fat diet (LCHFD) has shown promising results in obesity management, but its effects in preventing NAFLD need to be detailed. This study aims to compare the effects of a LCHFD with a high-fat high-sugar obesogenic Western diet (WD) on the progression of obesity, type 2 diabetes, and nonalcoholic fatty liver disease.
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Dates and versions

hal-04543122 , version 1 (11-04-2024)

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Anouk Charlot, Anthony Bringolf, Joris Mallard, Anne-Laure Charles, Nathalie Niederhoffer, et al.. Hypercaloric low-carbohydrate high-fat diet protects against the development of nonalcoholic fatty liver disease in obese mice in contrast to isocaloric Western diet.. Frontiers in Nutrition, 2024, 11, ⟨10.3389/fnut.2024.1366883⟩. ⟨hal-04543122⟩
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