Chapitre D'ouvrage Année : 2019

Micro/Nano Fabrication and Packaging Technologies for Bio Systems

Résumé

The investigation and development of micro/nano biosytem requires a sealed fluidic platform to separate, mix or control the flow of liquids and bio samples as well as a biochemical surface processing to selectively capture or repel biospecies. The first part of this chapter reviews the main techniques used for the fabrication of microchannels, reservoirs, pillars,… in various substrate materials. This includes direct machining techniques such as mechanical cutting, lithography and electroforming, as well as various replication techniques such as PDMS or UV curable resin casting, hot embossing and overall injection molding that is compatible with mass production. The second part describes the recent advances in the development of functionalized surfaces and their applications in biochips. First a focus is put on bioreceptors immobilization and a brief presentation of bioreceptors (antibodies and aptamers) is included. Next the polymers employed against plasmatic proteins fouling are reviewed and finally the surface chemistry preventing bacteria attachment is presented. The two approaches leading to bacteria repelling or killing, depending on the polymers employed, is discussed. The last chapter part is devoted to a critical analysis of bonding and welding techniques proposed to seal fluidic platforms.

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Dates et versions

hal-04541512 , version 1 (10-04-2024)

Identifiants

Citer

Yeong Eun Yoo, Claire Smadja, Mehdi Ammar. Micro/Nano Fabrication and Packaging Technologies for Bio Systems. Engineering of Micro/Nano Biosystems, Springer Singapore, pp.89-137, 2019, Microtechnology and MEMS, 978-981-13-6548-5. ⟨10.1007/978-981-13-6549-2_3⟩. ⟨hal-04541512⟩
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