Alcohol use disorder (AUD) is a public health issue that afects millions of people worldwide leading to physical, mental andsocio-economic consequences. While current treatments for AUD have provided relief to individuals, their efectiveness onthe long term is often limited, leaving a number of afected individuals without sustainable solutions. In this review, we aim toexplore two emerging approaches for AUD: psychedelics and epigenetic drugs (i.e., epidrugs). By examining preclinical studies,diferent animal species and procedures, we delve into the potential benefts of each of these treatments in terms of addictivebehaviors (alcohol drinking and seeking, motivation to drink alcohol and prevention of relapse). Because psychedelics andepidrugs may share common and complementary mechanisms of action, there is an exciting opportunity for exploring synergiesbetween these approaches and their parallel efectiveness in treating AUD and the diverse associated psychiatric conditions.