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Article Dans Une Revue Journal of Neural Transmission Année : 2024

Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies

Résumé

Alcohol use disorder (AUD) is a public health issue that afects millions of people worldwide leading to physical, mental and socio-economic consequences. While current treatments for AUD have provided relief to individuals, their efectiveness on the long term is often limited, leaving a number of afected individuals without sustainable solutions. In this review, we aim to explore two emerging approaches for AUD: psychedelics and epigenetic drugs (i.e., epidrugs). By examining preclinical studies, diferent animal species and procedures, we delve into the potential benefts of each of these treatments in terms of addictive behaviors (alcohol drinking and seeking, motivation to drink alcohol and prevention of relapse). Because psychedelics and epidrugs may share common and complementary mechanisms of action, there is an exciting opportunity for exploring synergies between these approaches and their parallel efectiveness in treating AUD and the diverse associated psychiatric conditions.

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Neurosciences
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Dates et versions

hal-04530543 , version 1 (03-04-2024)

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Fahd François Hilal, Jerome Jeanblanc, Chloé Deschamps, Mickael Naassila, Olivier Pierrefiche, et al.. Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies. Journal of Neural Transmission, 2024, ⟨10.1007/s00702-024-02757-3⟩. ⟨hal-04530543⟩

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