Raman Microimaging Using a Novel Multifiber-Based Device: A Feasibility Study on Pharmaceutical Tablets - Archive ouverte HAL
Article Dans Une Revue International Journal of Spectroscopy Année : 2012

Raman Microimaging Using a Novel Multifiber-Based Device: A Feasibility Study on Pharmaceutical Tablets

Résumé

Raman microimaging is a potential analytical technique in health field and presents many possible pharmaceutical applications. In this study, we tested a micrometer spatial resolution probe coupled to a portable Raman imager via an indexed multifiber bundle. At the level of the probe, the fibers were arranged in a circular geometry in order to fit to the pupil of an objective. The imaging potential of this Raman system was assessed on pharmaceutical-like pellets. We showed that this setup permits to record, nearly in real time, Raman images with a micrometer resolution. The collected images revealed a marked heterogeneity in chemicals distribution. Further investigations will be led on cells and biological tissues to evaluate the potential of this Raman imaging device for biomedical applications.
Fichier principal
Vignette du fichier
1_TFAILI-2012-International Journal of Spectroscopy.pdf (1.37 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-04529893 , version 1 (02-04-2024)

Licence

Identifiants

Citer

Sana Tfaili, Cyril Gobinet, Jean-François Angiboust, Michel Manfait, Olivier Piot. Raman Microimaging Using a Novel Multifiber-Based Device: A Feasibility Study on Pharmaceutical Tablets. International Journal of Spectroscopy, 2012, 2012, pp.959235. ⟨10.1155/2012/959235⟩. ⟨hal-04529893⟩

Collections

URCA BIOSPECT
54 Consultations
19 Téléchargements

Altmetric

Partager

More