Engineered Nanomaterials for Immunomodulation: A Review - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ACS Applied Bio Materials Année : 2024

Engineered Nanomaterials for Immunomodulation: A Review

Résumé

The immune system usually provides a defense against invading pathogenic microorganisms and any other particulate contaminants. Nonetheless, it has been recently reported that nanomaterials can evade the immune system and modulate immunological responses due to their unique physicochemical characteristics. Consequently, nanomaterial-based activation of immune components, i.e., neutrophils, macrophages, and other effector cells, may induce inflammation and alter the immune response. Here, it is essential to distinguish the acute and chronic modulations triggered by nanomaterials to determine the possible risks to human health. Nanomaterials size, shape, composition, surface charge, and deformability are factors controlling their uptake by immune cells and the resulting immune responses. The exterior corona of molecules adsorbed over nanomaterials surfaces also influences their immunological effects. Here, we review current nanoengineering trends for targeted immunomodulation with an emphasis on the design, safety, and potential toxicity of nanomaterials. First, we describe the characteristics of engineered nanomaterials that trigger immune responses. Then, the biocompatibility and immunotoxicity of nanoengineered particles are debated, because these factors influence applications. Finally, future nanomaterial developments in terms of surface modifications, synergistic approaches, and biomimetics are discussed.
Fichier sous embargo
Fichier sous embargo
0 2 0
Année Mois Jours
Avant la publication
jeudi 4 juillet 2024
Fichier sous embargo
jeudi 4 juillet 2024
Connectez-vous pour demander l'accès au fichier

Dates et versions

hal-04528415 , version 1 (01-04-2024)

Licence

Domaine public

Identifiants

Citer

Ragini Singh, Mamta Kumawat, Himanshu Gogoi, Harishkumar Madhyastha, Eric Lichtfouse, et al.. Engineered Nanomaterials for Immunomodulation: A Review. ACS Applied Bio Materials, 2024, 7, pp.727 - 751. ⟨10.1021/acsabm.3c00940⟩. ⟨hal-04528415⟩
1 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More