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Article Dans Une Revue Journal of Biophotonics Année : 2021

Raman confocal microscopy and biophysics multiparametric characterization of the skin barrier evolution with age

Résumé

Skin aging is a multifactorial phenomenon that involves alterations at the molecular, cellular, and tissue levels. Our aim was to carry out a multiparametric biophysical and Raman characterization of skin barrier between individuals of different age groups (<24 and > 70 years old). Our results showed a significant decrease of lipids to proteins ratio overall the thickness of the SC and higher lateral packing in the outer part of the SC for elderly. This can explain the decrease in TEWL measured values rather than only SC thickening. Both age groups showed similar water content at SC surface while elderly presented higher water content in deep SC and viable epidermis. Mechanical measurements showed a decrease in the elasticity and an increase in the fatigability with age and were correlated with partially bound water. Highest correlation and anti-correlation values were observed for the deepest part of the SC and the viable epidermis.
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Dates et versions

hal-04528043 , version 1 (03-04-2024)

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Aline Rigal-Dachaud, Rime Michael-Jubeli, Alex Nkengne, Arlette Baillet-Guffroy, Armelle Bigouret, et al.. Raman confocal microscopy and biophysics multiparametric characterization of the skin barrier evolution with age. Journal of Biophotonics, 2021, 14 (9), pp.e202100107. ⟨10.1002/jbio.202100107⟩. ⟨hal-04528043⟩
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