<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04526834</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-13T09:34:47+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Effect of Peg-IFN on the viral kinetics of HDV infected patients treated with bulevirtide</title>
            <author role="aut">
              <persName>
                <forename type="first">Selma</forename>
                <surname>El Messaoudi</surname>
              </persName>
              <idno type="idhal" notation="numeric">1369544</idno>
              <idno type="halauthorid" notation="string">225664-1369544</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2582-7798</idno>
              <affiliation ref="#struct-1005021"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Segolene</forename>
                <surname>Brichler</surname>
              </persName>
              <idno type="idhal" notation="numeric">1369545</idno>
              <idno type="halauthorid" notation="string">1063904-1369545</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7336-7730</idno>
              <affiliation ref="#struct-300210"/>
              <affiliation ref="#struct-266797"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claire</forename>
                <surname>Fougerou-Leurent</surname>
              </persName>
              <idno type="idhal" notation="numeric">1369546</idno>
              <idno type="halauthorid" notation="string">917700-1369546</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2736-6769</idno>
              <affiliation ref="#struct-35605"/>
              <affiliation ref="#struct-2610"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emmanuel</forename>
                <surname>Gordien</surname>
              </persName>
              <email type="md5">d56db6a0d14d2690c672fe5ed8536571</email>
              <email type="domain">aphp.fr</email>
              <idno type="idhal" notation="numeric">1052183</idno>
              <idno type="halauthorid" notation="string">121402-1052183</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2664-9417</idno>
              <affiliation ref="#struct-300210"/>
              <affiliation ref="#struct-266797"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Athenaïs</forename>
                <surname>Gerber</surname>
              </persName>
              <idno type="halauthorid">1056709-0</idno>
              <affiliation ref="#struct-300210"/>
              <affiliation ref="#struct-266797"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Amal</forename>
                <surname>Kortebi</surname>
              </persName>
              <idno type="halauthorid">3111685-0</idno>
              <affiliation ref="#struct-35605"/>
              <affiliation ref="#struct-2610"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Garance</forename>
                <surname>Lagadic</surname>
              </persName>
              <idno type="halauthorid">3111686-0</idno>
              <affiliation ref="#struct-35605"/>
              <affiliation ref="#struct-2610"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Miroslava</forename>
                <surname>Subic-Levrero</surname>
              </persName>
              <idno type="halauthorid">3111687-0</idno>
              <affiliation ref="#struct-300074"/>
              <affiliation ref="#struct-139829"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sophie</forename>
                <surname>Métivier</surname>
              </persName>
              <idno type="halauthorid">48954-0</idno>
              <affiliation ref="#struct-300075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stanislas</forename>
                <surname>Pol</surname>
              </persName>
              <idno type="idhal" notation="numeric">755799</idno>
              <idno type="halauthorid" notation="string">117457-755799</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9772-9591</idno>
              <affiliation ref="#struct-300123"/>
              <affiliation ref="#struct-300068"/>
              <affiliation ref="#struct-1004701"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne</forename>
                <surname>Minello</surname>
              </persName>
              <idno type="idhal" notation="numeric">1369547</idno>
              <idno type="halauthorid" notation="string">448109-1369547</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5014-5238</idno>
              <affiliation ref="#struct-1096458"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vlad</forename>
                <surname>Ratziu</surname>
              </persName>
              <idno type="idhal" notation="numeric">762368</idno>
              <idno type="halauthorid" notation="string">448180-762368</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6865-3791</idno>
              <affiliation ref="#struct-300068"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Leroy</surname>
              </persName>
              <email type="md5">1386466808da35f00e1c976cc2932fe4</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">vincent-leroy</idno>
              <idno type="idhal" notation="numeric">4745</idno>
              <idno type="halauthorid" notation="string">7566-4745</idno>
              <idno type="IDREF">https://www.idref.fr/152407219</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3464-726X</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5372-4334</idno>
              <affiliation ref="#struct-1042703"/>
              <affiliation ref="#struct-1043222"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Mathurin</surname>
              </persName>
              <idno type="idhal" notation="numeric">764669</idno>
              <idno type="halauthorid" notation="string">155576-764669</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4800-1841</idno>
              <idno type="IDREF">https://www.idref.fr/174165412</idno>
              <affiliation ref="#struct-2656"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Alric</surname>
              </persName>
              <email type="md5">fc9ef60ecbae3950a8b424c379c83ee9</email>
              <email type="domain">chu-toulouse.fr</email>
              <idno type="idhal" notation="numeric">881462</idno>
              <idno type="halauthorid" notation="string">501440-881462</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0676-7539</idno>
              <affiliation ref="#struct-217752"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fatoumata</forename>
                <surname>Coulibaly</surname>
              </persName>
              <email type="md5">e2046bb363bb1ea9718c25e985dd5fd1</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">1341846</idno>
              <idno type="halauthorid" notation="string">723377-1341846</idno>
              <affiliation ref="#struct-1083834"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Michel</forename>
                <surname>Pawlotsky</surname>
              </persName>
              <email type="md5">8e861156d17b1d0cbe511e0d92aa2f5e</email>
              <email type="domain">hmn.aphp.fr</email>
              <idno type="idhal" notation="numeric">757187</idno>
              <idno type="halauthorid" notation="string">172300-757187</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0745-7559</idno>
              <idno type="IDREF">https://www.idref.fr/07655130X</idno>
              <affiliation ref="#struct-266797"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabien</forename>
                <surname>Zoulim</surname>
              </persName>
              <email type="md5">1b537b3af1d61f5280a8156d57091367</email>
              <email type="domain">lyon.inserm.fr</email>
              <idno type="idhal" notation="string">fabien-zoulim</idno>
              <idno type="idhal" notation="numeric">890662</idno>
              <idno type="halauthorid" notation="string">172321-890662</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2245-0083</idno>
              <affiliation ref="#struct-300074"/>
              <affiliation ref="#struct-139829"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Victor</forename>
                <surname>de Ledinghen</surname>
              </persName>
              <idno type="idhal" notation="numeric">756883</idno>
              <idno type="halauthorid" notation="string">159892-756883</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6414-1951</idno>
              <affiliation ref="#struct-476572"/>
              <affiliation ref="#struct-1136195"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jérémie</forename>
                <surname>Guedj</surname>
              </persName>
              <idno type="idhal" notation="numeric">757106</idno>
              <idno type="halauthorid" notation="string">168858-757106</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5534-5482</idno>
              <idno type="IDREF">https://www.idref.fr/11391184X</idno>
              <affiliation ref="#struct-1005021"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laurent</forename>
                <surname>Jonchère</surname>
              </persName>
              <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
              <email type="domain">univ-rennes.fr</email>
            </editor>
            <funder>Gilead Sciences</funder>
            <funder>Agence Nationale de Recherches sur le Sida et les Hépatites Virales</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-09-24 11:36:37</date>
              <date type="whenModified">2026-04-02 15:54:04</date>
              <date type="whenReleased">2024-09-24 11:36:38</date>
              <date type="whenProduced">2024</date>
              <date type="whenEndEmbargoed">2024-09-24</date>
              <ref type="file" target="https://hal.science/hal-04526834v1/document">
                <date notBefore="2024-09-24"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-04526834v1/file/PIIS2589555924000715.pdf" id="file-4707330-4094638">
                <date notBefore="2024-09-24"/>
              </ref>
              <ref type="annex" n="0" target="https://hal.science/hal-04526834v1/file/ScienceDirect_files_24Sep2024_09-36-07.551.zip" id="file-4707330-4094639">
                <date notBefore="2024-09-24"/>
              </ref>
              <ref type="externalLink" target="http://www.jhep-reports.eu/article/S2589555924000715/pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="113861">
                <persName>
                  <forename>Laurent</forename>
                  <surname>Jonchère</surname>
                </persName>
                <email type="md5">dc1f1e9bdb3dc2065f8bf1bfd5663118</email>
                <email type="domain">univ-rennes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04526834</idno>
            <idno type="halUri">https://hal.science/hal-04526834</idno>
            <idno type="halBibtex">elmessaoudi:hal-04526834</idno>
            <idno type="halRefHtml">&lt;i&gt;JHEP Reports Innovation in Hepatology&lt;/i&gt;, 2024, 6 (8), pp.101070. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.jhepr.2024.101070"&gt;&amp;#x27E8;10.1016/j.jhepr.2024.101070&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">JHEP Reports Innovation in Hepatology, 2024, 6 (8), pp.101070. &amp;#x27E8;10.1016/j.jhepr.2024.101070&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-4707330-4094638"/><ref corresp="#file-4707330-4094639"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno>
            <idno type="stamp" n="UNIV-BOURGOGNE">Université Bourgogne Europe</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="ANRS">Agence Nationale de Recherches sur le Sida</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="IMRB" corresp="INSERM">Institut Mondor de Recherche Biomédicale</idno>
            <idno type="stamp" n="UPEC" corresp="CV_UPEC">Université Paris-Est Créteil Val-de-Marne</idno>
            <idno type="stamp" n="HL">Publications CHU Rennes</idno>
            <idno type="stamp" n="CIC">CIC-Rennes</idno>
            <idno type="stamp" n="CIC203">CIC-1414</idno>
            <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno>
            <idno type="stamp" n="NUMECAN">Nutrition, Métabolismes et Cancer</idno>
            <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno>
            <idno type="stamp" n="LNC-UMR866" corresp="UNIV-BOURGOGNE">Lipides Nutrition Cancer - UMR866</idno>
            <idno type="stamp" n="IAME" corresp="UNIV-PARIS13">Infection, Anti-microbiens, Modélisation, Evolution - UMR 1137</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="CRCL" corresp="UNIV-LYON1">Centre de recherche en cancérologie de Lyon (UMR INSERM 1052 ; CNRS 5286 ; Centre Léon Bérard)</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="IBHGC" corresp="UNIV-PARIS13">Institut de Biomécanique Humaine Georges Charpak</idno>
            <idno type="stamp" n="SORBONNE-PARIS-NORD">Université Sorbonne Paris Nord</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="UR1-BIO-SA">Pôle UnivRennes - Biologie-Santé</idno>
            <idno type="stamp" n="U1219" corresp="INSERM">Bordeaux Population Health</idno>
            <idno type="stamp" n="CRCL-EQUIPE-F-ZOULIM" corresp="CRCL">CRCL-Virus hépatiques et pathobiologie des maladies chroniques hépatiques</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="ACT-R" corresp="UNIV-PARIS13">Act'R </idno>
            <idno type="stamp" n="RESTORE">RESTORE</idno>
            <idno type="stamp" n="INSTITUT-AGRO">Institut Agro</idno>
            <idno type="stamp" n="CTM_UMR1231" corresp="UNIV-BOURGOGNE">CTM</idno>
            <idno type="stamp" n="UNIVERSITE-BORDEAUX">Université de Bordeaux</idno>
            <idno type="stamp" n="IAB_GRENOBLE">IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)</idno>
            <idno type="stamp" n="TEST-UPEC-ODD" corresp="UPEC">TEST UPEC ODD</idno>
            <idno type="stamp" n="BRIC">BoRdeaux Institute in onCology</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Effect of Peg-IFN on the viral kinetics of HDV infected patients treated with bulevirtide</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Selma</forename>
                    <surname>El Messaoudi</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1369544</idno>
                  <idno type="halauthorid" notation="string">225664-1369544</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2582-7798</idno>
                  <affiliation ref="#struct-1005021"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Segolene</forename>
                    <surname>Brichler</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1369545</idno>
                  <idno type="halauthorid" notation="string">1063904-1369545</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7336-7730</idno>
                  <affiliation ref="#struct-300210"/>
                  <affiliation ref="#struct-266797"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claire</forename>
                    <surname>Fougerou-Leurent</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1369546</idno>
                  <idno type="halauthorid" notation="string">917700-1369546</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2736-6769</idno>
                  <affiliation ref="#struct-35605"/>
                  <affiliation ref="#struct-2610"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emmanuel</forename>
                    <surname>Gordien</surname>
                  </persName>
                  <email type="md5">d56db6a0d14d2690c672fe5ed8536571</email>
                  <email type="domain">aphp.fr</email>
                  <idno type="idhal" notation="numeric">1052183</idno>
                  <idno type="halauthorid" notation="string">121402-1052183</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2664-9417</idno>
                  <affiliation ref="#struct-300210"/>
                  <affiliation ref="#struct-266797"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Athenaïs</forename>
                    <surname>Gerber</surname>
                  </persName>
                  <idno type="halauthorid">1056709-0</idno>
                  <affiliation ref="#struct-300210"/>
                  <affiliation ref="#struct-266797"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Amal</forename>
                    <surname>Kortebi</surname>
                  </persName>
                  <idno type="halauthorid">3111685-0</idno>
                  <affiliation ref="#struct-35605"/>
                  <affiliation ref="#struct-2610"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Garance</forename>
                    <surname>Lagadic</surname>
                  </persName>
                  <idno type="halauthorid">3111686-0</idno>
                  <affiliation ref="#struct-35605"/>
                  <affiliation ref="#struct-2610"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Miroslava</forename>
                    <surname>Subic-Levrero</surname>
                  </persName>
                  <idno type="halauthorid">3111687-0</idno>
                  <affiliation ref="#struct-300074"/>
                  <affiliation ref="#struct-139829"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sophie</forename>
                    <surname>Métivier</surname>
                  </persName>
                  <idno type="halauthorid">48954-0</idno>
                  <affiliation ref="#struct-300075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stanislas</forename>
                    <surname>Pol</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">755799</idno>
                  <idno type="halauthorid" notation="string">117457-755799</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9772-9591</idno>
                  <affiliation ref="#struct-300123"/>
                  <affiliation ref="#struct-300068"/>
                  <affiliation ref="#struct-1004701"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne</forename>
                    <surname>Minello</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1369547</idno>
                  <idno type="halauthorid" notation="string">448109-1369547</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5014-5238</idno>
                  <affiliation ref="#struct-1096458"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vlad</forename>
                    <surname>Ratziu</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">762368</idno>
                  <idno type="halauthorid" notation="string">448180-762368</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6865-3791</idno>
                  <affiliation ref="#struct-300068"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincent</forename>
                    <surname>Leroy</surname>
                  </persName>
                  <email type="md5">1386466808da35f00e1c976cc2932fe4</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">vincent-leroy</idno>
                  <idno type="idhal" notation="numeric">4745</idno>
                  <idno type="halauthorid" notation="string">7566-4745</idno>
                  <idno type="IDREF">https://www.idref.fr/152407219</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3464-726X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5372-4334</idno>
                  <affiliation ref="#struct-1042703"/>
                  <affiliation ref="#struct-1043222"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Mathurin</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">764669</idno>
                  <idno type="halauthorid" notation="string">155576-764669</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4800-1841</idno>
                  <idno type="IDREF">https://www.idref.fr/174165412</idno>
                  <affiliation ref="#struct-2656"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Alric</surname>
                  </persName>
                  <email type="md5">fc9ef60ecbae3950a8b424c379c83ee9</email>
                  <email type="domain">chu-toulouse.fr</email>
                  <idno type="idhal" notation="numeric">881462</idno>
                  <idno type="halauthorid" notation="string">501440-881462</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0676-7539</idno>
                  <affiliation ref="#struct-217752"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fatoumata</forename>
                    <surname>Coulibaly</surname>
                  </persName>
                  <email type="md5">e2046bb363bb1ea9718c25e985dd5fd1</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">1341846</idno>
                  <idno type="halauthorid" notation="string">723377-1341846</idno>
                  <affiliation ref="#struct-1083834"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Michel</forename>
                    <surname>Pawlotsky</surname>
                  </persName>
                  <email type="md5">8e861156d17b1d0cbe511e0d92aa2f5e</email>
                  <email type="domain">hmn.aphp.fr</email>
                  <idno type="idhal" notation="numeric">757187</idno>
                  <idno type="halauthorid" notation="string">172300-757187</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0745-7559</idno>
                  <idno type="IDREF">https://www.idref.fr/07655130X</idno>
                  <affiliation ref="#struct-266797"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabien</forename>
                    <surname>Zoulim</surname>
                  </persName>
                  <email type="md5">1b537b3af1d61f5280a8156d57091367</email>
                  <email type="domain">lyon.inserm.fr</email>
                  <idno type="idhal" notation="string">fabien-zoulim</idno>
                  <idno type="idhal" notation="numeric">890662</idno>
                  <idno type="halauthorid" notation="string">172321-890662</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2245-0083</idno>
                  <affiliation ref="#struct-300074"/>
                  <affiliation ref="#struct-139829"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Victor</forename>
                    <surname>de Ledinghen</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">756883</idno>
                  <idno type="halauthorid" notation="string">159892-756883</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6414-1951</idno>
                  <affiliation ref="#struct-476572"/>
                  <affiliation ref="#struct-1136195"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jérémie</forename>
                    <surname>Guedj</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">757106</idno>
                  <idno type="halauthorid" notation="string">168858-757106</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5534-5482</idno>
                  <idno type="IDREF">https://www.idref.fr/11391184X</idno>
                  <affiliation ref="#struct-1005021"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">160764</idno>
                <idno type="eissn">2589-5559</idno>
                <title level="j">JHEP Reports  Innovation in Hepatology</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">6</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">101070</biblScope>
                  <date type="datePub">2024</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.jhepr.2024.101070</idno>
              <idno type="pubmed">39100818</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Viral kinetics</term>
                <term xml:lang="en">Hepatitis Delta virus</term>
                <term xml:lang="en">Antiviral treatment</term>
                <term xml:lang="en">Peg-IFN</term>
                <term xml:lang="en">Bulevirtide</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background &amp; aims - Bulevirtide is a first-in-class entry inhibitor antiviral treatment for chronic hepatitis D. The viral kinetics during bulevirtide therapy and the effect of combining bulevirtide with pegylated-interferon (Peg-IFN) are unknown.  Methods - We used mathematical modelling to analyze the viral kinetics in two French observational cohorts of 183 patients receiving bulevirtide with or without Peg-IFN for 48 weeks.  Results - The efficacy of bulevirtide in blocking cell infection was estimated to 90.3%, whereas Peg-IFN blocked viral production with an efficacy of 92.4%, albeit with large inter-individual variabilities. The addition of Peg-IFN to bulevirtide was associated with a more rapid virological decline, with a rate of virological response (&gt;2 log of decline or undetectability) at week 48 of 86.9% (95% prediction interval [PI] = [79.7-95.0]), compared with 56.1% (95% PI = [46.4-66.7]) with bulevirtide only. The model was also used to predict the probability to achieve a cure of viral infection, with a rate of 8.8% (95% PI = [3.5-13.2]) with bulevirtide compared with 18.8% (95% PI = [11.6-29.0]) with bulevirtide + Peg-IFN. Mathematical modelling suggests that after 144 weeks of treatment, the rates of viral cure could be 42.1% (95% PI = [33.3-52.6]) with bulevirtide and 66.7% (95% PI = [56.5-76.8]) with bulevirtide + Peg-IFN.  Conclusions - In this analysis of real-world data, Peg-IFN strongly enhanced the kinetics of viral decline in patients treated with bulevirtide. Randomized clinical trials are warranted to assess the virological and clinical benefit of this combination, and to identify predictors of poor response to treatment.  Impact and implications - Bulevirtide has been approved for chronic HDV infection by regulatory agencies in Europe based on its good safety profile and rapid virological response after treatment initiation, but the optimal duration of treatment and the chance to achieve a sustained virological response remain unknown. The results presented in this study have a high impact for clinicians and investigators as they provide important knowledge on the long-term virological benefits of a combination of Peg-IFN and bulevirtide in patients with CHD. Clinical trials are now warranted to confirm those predictions.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1005021" status="VALID">
          <idno type="IdRef">235514829</idno>
          <idno type="RNSR">201420743R</idno>
          <orgName>Infection, Anti-microbiens, Modélisation, Evolution</orgName>
          <orgName type="acronym">IAME (UMR_S_1137 / U1137)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de médecine Paris Diderot Paris 7 - site Bichat - 16 rue Henri Huchard 75890 Paris Cedex 18</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.iame-research.center/</ref>
          </desc>
          <listRelation>
            <relation name="U1137" active="#struct-303623" type="direct"/>
            <relation name="UMR_S_1137" active="#struct-557826" type="direct"/>
            <relation active="#struct-581146" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300210" status="VALID">
          <idno type="IdRef">030351189</idno>
          <idno type="ROR">https://ror.org/03n6vs369</idno>
          <orgName>Hôpital Avicenne [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>125, rue de Stalingrad 93000 Bobigny</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://chu93.aphp.fr/hopital-avicenne-bobigny/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-266797" status="VALID">
          <idno type="IdRef">151294895</idno>
          <idno type="RNSR">200919261B</idno>
          <idno type="ROR">https://ror.org/04qe59j94</idno>
          <idno type="Wikidata">Q30261452</idno>
          <orgName>Institut Mondor de Recherche Biomédicale</orgName>
          <orgName type="acronym">IMRB</orgName>
          <desc>
            <address>
              <addrLine>8 rue du Général Sarrail 94010 Créteil</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.imrb.inserm.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U955" active="#struct-303623" type="direct"/>
            <relation name="UMR955" active="#struct-420786" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-35605" status="VALID">
          <idno type="ROR">https://ror.org/05qec5a53</idno>
          <orgName>Centre Hospitalier Universitaire [Rennes]</orgName>
          <desc>
            <address>
              <addrLine>rue H. Le Guillou 35033 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-rennes.fr/page_accueil/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-2610" status="VALID">
          <idno type="RNSR">200220115K</idno>
          <idno type="ROR">https://ror.org/02baj6743</idno>
          <orgName>Centre d'Investigation Clinique [Rennes]</orgName>
          <orgName type="acronym">CIC</orgName>
          <date type="start">2002-01-01</date>
          <desc>
            <address>
              <addrLine>Rue Henri Le Guilloux - Pavillon Clémenceau 35033 Rennes Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cic-rennes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation active="#struct-301327" type="direct"/>
            <relation name="CIC1414" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-139829" status="VALID">
          <idno type="IdRef">17153770X</idno>
          <idno type="ISNI">0000 0004 0384 0005</idno>
          <idno type="RNSR">201119413H</idno>
          <idno type="ROR">https://ror.org/02mgw3155</idno>
          <orgName>Centre de Recherche en Cancérologie de Lyon</orgName>
          <orgName type="acronym">UNICANCER/CRCL</orgName>
          <date type="start">2011-01-01</date>
          <desc>
            <address>
              <addrLine>28, rue Laennec - 69373 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.crcl.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-20549" type="direct"/>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation name="U1052" active="#struct-303623" type="direct"/>
            <relation name="UMR5286" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300075" status="VALID">
          <orgName>Centre Hospitalier Universitaire de Toulouse</orgName>
          <orgName type="acronym">CHU Toulouse</orgName>
          <desc>
            <address>
              <addrLine>regroupe les hôpitaux  Purpan, Rangueil, Pierre-Paul Riquet, Larey, Paule de Viguier, Hôtel Dieu Saint-Jacques, La Grave, etc.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-toulouse.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300123" status="VALID">
          <idno type="IdRef">030428653</idno>
          <idno type="ROR">https://ror.org/00ph8tk69</idno>
          <orgName>Hôpital Cochin [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1004701" status="VALID">
          <idno type="IdRef">158485130</idno>
          <idno type="ISNI">0000 0004 0643 431X</idno>
          <idno type="RNSR">200217519N</idno>
          <idno type="ROR">https://ror.org/051sk4035</idno>
          <orgName>Institut Cochin</orgName>
          <orgName type="acronym">IC UM3 (UMR 8104 / U1016)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>22 rue Méchain, 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://cochin.inserm.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1016" active="#struct-303623" type="direct"/>
            <relation name="UMR8104" active="#struct-441569" type="direct"/>
            <relation name="UM 3" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1096458" status="OLD">
          <idno type="IdRef">15975979X</idno>
          <idno type="RNSR">200716508T</idno>
          <idno type="ROR">https://ror.org/04d70nb60</idno>
          <orgName>Lipides - Nutrition - Cancer [Dijon - U1231]</orgName>
          <orgName type="acronym">LNC</orgName>
          <date type="start">2022-01-01</date>
          <date type="end">2023-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Bourgogne - Faculte de medecine - 7, boulevard Jeanne d'Arc - BP 87900 - 21079 Dijon Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://inserm-u866.u-bourgogne.fr/index.php</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300270" type="direct"/>
            <relation name="U1231" active="#struct-303623" type="direct"/>
            <relation name="UMR_S 866" active="#struct-1096329" type="direct"/>
            <relation active="#struct-1042499" type="indirect"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1043222" status="VALID">
          <idno type="IdRef">200912658</idno>
          <idno type="RNSR">201622378J</idno>
          <idno type="ROR">https://ror.org/05kwbf598</idno>
          <orgName>Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)</orgName>
          <orgName type="acronym">IAB</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Institut pour l'Avancée des BiosciencesCentre de Recherche UGA / Inserm U 1209 / CNRS UMR 5309Site Santé - Allée des Alpes 38700 La Tronche</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://iab-grenoble.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-200221" type="direct"/>
            <relation active="#struct-199980" type="indirect"/>
            <relation active="#struct-257328" type="direct"/>
            <relation name="U1209" active="#struct-303623" type="direct"/>
            <relation name="UMR5309" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-2656" status="OLD">
          <orgName>Physiopathologie des Maladies Inflammatoires de l'Intestin</orgName>
          <desc>
            <address>
              <addrLine>Hopital Pierre Swynghedauw , Rue Andre Verhaeghe 59037 LILLE CEDEX</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="U795" active="#struct-303623" type="direct"/>
            <relation active="#struct-361611" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1083834" status="VALID">
          <orgName>ANRS - Maladies infectieuses émergentes</orgName>
          <orgName type="acronym">ANRS - MIE</orgName>
          <desc>
            <address>
              <addrLine>101 rue de Tolbiac 75013 paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.anrs.fr/fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-476572" status="VALID">
          <idno type="IdRef">197398162</idno>
          <idno type="RNSR">201622170H</idno>
          <idno type="ROR">https://ror.org/00xzzba89</idno>
          <orgName>Bordeaux population health</orgName>
          <orgName type="acronym">BPH</orgName>
          <desc>
            <address>
              <addrLine>Université de Bordeaux - Case 11 - 146 rue Léo Saignat  33076 Bordeaux cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-259761" type="direct"/>
            <relation active="#struct-302259" type="direct"/>
            <relation name="U1219" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1136195" status="VALID">
          <orgName>BoRdeaux Institute of onCology</orgName>
          <orgName type="acronym">Inserm U1312 - BRIC</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.bricbordeaux.com/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-259761" type="direct"/>
            <relation name="U1312" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-581146" status="VALID">
          <idno type="IdRef">02640463X</idno>
          <idno type="ISNI">0000000121496883</idno>
          <idno type="ROR">https://ror.org/0199hds37</idno>
          <orgName>Université Sorbonne Paris Nord</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>99, avenue Jean-Baptiste Clément, 93430 Villetaneuse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-paris13.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-420786" status="VALID">
          <idno type="IdRef">028021037</idno>
          <idno type="ISNI">0000000121497878</idno>
          <idno type="ROR">https://ror.org/05ggc9x40</idno>
          <orgName>Université Paris-Est Créteil Val-de-Marne - Paris 12</orgName>
          <orgName type="acronym">UPEC UP12</orgName>
          <date type="start">1970-01-01</date>
          <desc>
            <address>
              <addrLine>61 avenue du Général de Gaulle - 94010 Créteil cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-pec.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301327" status="VALID">
          <idno type="ROR">https://ror.org/05qec5a53</idno>
          <orgName>Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]</orgName>
          <desc>
            <address>
              <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-20549" status="VALID">
          <idno type="ROR">https://ror.org/01cmnjq37</idno>
          <orgName>Centre Léon Bérard [Lyon]</orgName>
          <desc>
            <address>
              <addrLine>28, rue Laennec 69373 LYON Cedex 08</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.centreleonberard.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300270" status="OLD">
          <idno type="IdRef">02819005X</idno>
          <idno type="ISNI">0000000122989313</idno>
          <idno type="ROR">https://ror.org/03k1bsr36</idno>
          <orgName>Université de Bourgogne</orgName>
          <orgName type="acronym">UB</orgName>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>Maison de l'université - Esplanade Érasme - BP 27877 - 21078 Dijon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-bourgogne.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1096329" status="VALID">
          <idno type="IdRef">261024671</idno>
          <idno type="ROR">https://ror.org/03zek0r74</idno>
          <idno type="Wikidata">Q8077943</idno>
          <orgName>Institut Agro Dijon</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>26 Boulevard du Dr Petitjean - BP 87999 - 21079 Dijon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://institut-agro-dijon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042499" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042499" status="VALID">
          <idno type="IdRef">260373249</idno>
          <idno type="ROR">https://ror.org/01dkyve95</idno>
          <orgName>Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement</orgName>
          <orgName type="acronym">Institut Agro</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institut-agro.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-200221" status="VALID">
          <orgName>Établissement Français du Sang Auvergne-Rhône-Alpes [Lyon]</orgName>
          <orgName type="acronym">EFS Auvergne-Rhône-Alpes - Lyon</orgName>
          <desc>
            <address>
              <addrLine>Site de Lyon. 3 Rue du Vercors 69364 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.efs.sante.fr/lefs-en-auvergne-rhone-alpes</ref>
          </desc>
          <listRelation>
            <relation active="#struct-199980" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-199980" status="VALID">
          <orgName>Établissement Français du Sang [La Plaine Saint-Denis]</orgName>
          <orgName type="acronym">EFS</orgName>
          <date type="start">2000-01-01</date>
          <desc>
            <address>
              <addrLine>20 Avenue du Stade de France 93218 La Plaine Saint Denis</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.dondusang.net</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-257328" status="VALID">
          <idno type="IdRef">034137076</idno>
          <idno type="ROR">https://ror.org/041rhpw39</idno>
          <orgName>CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble</orgName>
          <orgName type="acronym">CHUGA</orgName>
          <desc>
            <address>
              <addrLine>CS 1021738043 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-361611" status="OLD">
          <idno type="IdRef">026404389</idno>
          <idno type="ISNI">0000000120977060</idno>
          <orgName>Université de Lille, Droit et Santé</orgName>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>42 rue Paul Duez 59000 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lille2.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-259761" status="VALID">
          <idno type="IdRef">175206562</idno>
          <idno type="ROR">https://ror.org/057qpr032</idno>
          <orgName>Université de Bordeaux</orgName>
          <orgName type="acronym">UB</orgName>
          <desc>
            <address>
              <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-bordeaux.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302259" status="VALID">
          <orgName>Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>