Objective: The aims were to: (1) apply the guidelines to develop and test the validity of video-vignettes manipulating empathy and context in oncology; (2) compare lay people’s and patients’ assessments of validity; (3) reflecting on our experiment Methods: Guidelines were followed: (1) deciding whether video-vignettes were appropriate; (2) developing a valid script; (3) designing valid manipulations; (4) converting the scripted consultations into videos. One hundred sixteen lay people and 46 cancer patients filled in the Video Engagement Scale, the CARE, and ad hoc questionnaires on realism and emotions. Results: The video-vignettes are valid for experimental use. Differences appeared in the emotions participants reported. The empathic processes were successfully manipulated and perceived. Lay people’s and patients’ assessments were equivalent, except for video-vignettes in neutral consultations. Participants’ comments on nonverbal behavior, camera perspective, scripts and empathy assessment were reported. Conclusion: Patients’ assessments are impacted by their personal experiences. Researchers should control for this in analogue patient studies.