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                <title level="j">Cancers</title>
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                  <publisher>MDPI</publisher>
                  <biblScope unit="volume">15</biblScope>
                  <biblScope unit="issue">7</biblScope>
                  <biblScope unit="pp">2188</biblScope>
                  <date type="datePub">2023-04-06</date>
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                <term xml:lang="en">esogastric adenocarcinoma</term>
                <term xml:lang="en">neoadjuvant chemotherapy</term>
                <term xml:lang="en">cetuximab</term>
                <term xml:lang="en">surgery</term>
                <term xml:lang="en">efficacy</term>
                <term xml:lang="en">safety</term>
                <term xml:lang="en">EGFR-1</term>
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              <p>Purpose: While perioperative chemotherapy provides a survival benefit over surgery alone in gastric and gastroesophageal junction (G/GEJ) adenocarcinomas, the results need to be improved. This study aimed to evaluate the efficacy and safety of perioperative cetuximab combined with 5-fluorouracil and cisplatin. Patients and Methods: Patients received six cycles of cetuximab, cisplatin, and simplified LV5FU2 before and after surgery. The primary objective was a combined evaluation of the tumor objective response (TOR), assessed by computed tomography, and the absence of major toxicities resulting in discontinuation of neoadjuvant chemotherapy (NCT) (45% and 90%, respectively). Results: From 2011 to 2013, 65 patients were enrolled. From 64 patients evaluable for the primary endpoint, 19 (29.7%) had a morphological TOR and 61 (95.3%) did not stop NCT prematurely due to major toxicity. Sixty patients (92.3%) underwent resection. Sixteen patients (/56 available, 28.5%) had histological responses (Mandard tumor regression grade ≤3). After a median follow-up of 44.5 months, median disease-free and overall survival were 24.4 [95% CI: 16.4-39.4] and 40.3 months [95% CI: 27.5-NA], respectively. Conclusion: Adding cetuximab to the NCT regimen in operable G/GEJ adenocarcinomas is safe, but did not show enough efficacy in the present study to meet the primary endpoint (NCT01360086).</p>
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