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            <title xml:lang="en">Delayed Surgical Intervention After Chemoradiotherapy in Esophageal Cancer</title>
            <author role="aut">
              <persName>
                <forename type="first">Swathikan</forename>
                <surname>Chidambaram</surname>
              </persName>
              <idno type="halauthorid">3099268-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Richard</forename>
                <surname>Owen</surname>
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              <idno type="halauthorid">3082884-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bruno</forename>
                <surname>Sgromo</surname>
              </persName>
              <idno type="halauthorid">2351941-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Magdalena</forename>
                <surname>Chmura</surname>
              </persName>
              <idno type="halauthorid">3099269-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aaron</forename>
                <surname>Kisiel</surname>
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              <persName>
                <forename type="first">Richard</forename>
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                <forename type="first">Ewen</forename>
                <surname>Griffiths</surname>
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                <forename type="first">Carlo</forename>
                <surname>Castoro</surname>
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            <author role="aut">
              <persName>
                <forename type="first">Caroline</forename>
                <surname>Gronnier</surname>
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              <idno type="halauthorid">843059-0</idno>
              <affiliation ref="#struct-301071"/>
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            <author role="aut">
              <persName>
                <forename type="first">Mometo Ali</forename>
                <surname>Maoawyes</surname>
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              <idno type="halauthorid">3099271-0</idno>
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            <author role="aut">
              <persName>
                <forename type="first">Christian</forename>
                <surname>Gutschow</surname>
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              <persName>
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                <surname>Piessen</surname>
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                <surname>Degisors</surname>
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              <persName>
                <forename type="first">Rita</forename>
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              <persName>
                <forename type="first">Hope</forename>
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              <persName>
                <forename type="first">Giovanni</forename>
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                <surname>Gossage</surname>
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              <persName>
                <forename type="first">Dan</forename>
                <surname>Voeten</surname>
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              <persName>
                <forename type="first">Suzanne</forename>
                <surname>Gisbertz</surname>
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                <surname>Ruurda</surname>
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                <forename type="first">George</forename>
                <surname>Hanna</surname>
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              <persName>
                <forename type="first">Nick</forename>
                <surname>Maynard</surname>
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                <forename type="first">Wayne</forename>
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                <forename type="first">Lorenzo</forename>
                <surname>Ferri</surname>
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            <author role="aut">
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                <forename type="first">Mark</forename>
                <surname>Berge Henegouwen</surname>
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                <forename type="first">Sheraz</forename>
                <surname>Markar</surname>
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                <forename>Nicolas</forename>
                <surname>Jonckheere</surname>
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              <date type="whenSubmitted">2024-03-26 15:04:17</date>
              <date type="whenModified">2025-05-13 11:30:54</date>
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            <idno type="halRefHtml">&lt;i&gt;Annals of Surgery&lt;/i&gt;, 2023, 278 (5), pp.701-708. &lt;a target="_blank" href="https://dx.doi.org/10.1097/SLA.0000000000006028"&gt;&amp;#x27E8;10.1097/SLA.0000000000006028&amp;#x27E9;&lt;/a&gt;</idno>
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            <idno type="stamp" n="RIIP">Pasteur Network</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="RIIP_LILLE" corresp="RIIP">Institut Pasteur de Lille</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="CANTHER">Cancer heterogeneity, plasticity and resistance to therapies</idno>
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                <title xml:lang="en">Delayed Surgical Intervention After Chemoradiotherapy in Esophageal Cancer</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Swathikan</forename>
                    <surname>Chidambaram</surname>
                  </persName>
                  <idno type="halauthorid">3099268-0</idno>
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                <author role="aut">
                  <persName>
                    <forename type="first">Richard</forename>
                    <surname>Owen</surname>
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                  <persName>
                    <forename type="first">Bruno</forename>
                    <surname>Sgromo</surname>
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                <author role="aut">
                  <persName>
                    <forename type="first">Magdalena</forename>
                    <surname>Chmura</surname>
                  </persName>
                  <idno type="halauthorid">3099269-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aaron</forename>
                    <surname>Kisiel</surname>
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                  <idno type="halauthorid">3099270-0</idno>
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                <author role="aut">
                  <persName>
                    <forename type="first">Richard</forename>
                    <surname>Evans</surname>
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                  <idno type="halauthorid">1066193-0</idno>
                  <affiliation ref="#struct-26672"/>
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                <author role="aut">
                  <persName>
                    <forename type="first">Ewen</forename>
                    <surname>Griffiths</surname>
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                <author role="aut">
                  <persName>
                    <forename type="first">Carlo</forename>
                    <surname>Castoro</surname>
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                  <idno type="halauthorid">1703183-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Caroline</forename>
                    <surname>Gronnier</surname>
                  </persName>
                  <idno type="halauthorid">843059-0</idno>
                  <affiliation ref="#struct-301071"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mometo Ali</forename>
                    <surname>Maoawyes</surname>
                  </persName>
                  <idno type="halauthorid">3099271-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christian</forename>
                    <surname>Gutschow</surname>
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                  <idno type="halauthorid">1285626-0</idno>
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                <author role="aut">
                  <persName>
                    <forename type="first">Guillaume</forename>
                    <surname>Piessen</surname>
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                <author role="aut">
                  <persName>
                    <forename type="first">Sébastien</forename>
                    <surname>Degisors</surname>
                  </persName>
                  <idno type="halauthorid">3091353-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rita</forename>
                    <surname>Alvieri</surname>
                  </persName>
                  <idno type="halauthorid">3099272-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hope</forename>
                    <surname>Feldman</surname>
                  </persName>
                  <idno type="halauthorid">3099273-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Giovanni</forename>
                    <surname>Capovilla</surname>
                  </persName>
                  <idno type="halauthorid">3099274-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Peter</forename>
                    <surname>Grimminger</surname>
                  </persName>
                  <idno type="halauthorid">2870157-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Shiwei</forename>
                    <surname>Han</surname>
                  </persName>
                  <idno type="halauthorid">3099275-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Donald</forename>
                    <surname>Low</surname>
                  </persName>
                  <idno type="halauthorid">3099276-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jonathan</forename>
                    <surname>Moore</surname>
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                  <idno type="halauthorid">1615899-0</idno>
                  <affiliation ref="#struct-302824"/>
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                  <persName>
                    <forename type="first">James</forename>
                    <surname>Gossage</surname>
                  </persName>
                  <idno type="halauthorid">3099277-0</idno>
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                <author role="aut">
                  <persName>
                    <forename type="first">Dan</forename>
                    <surname>Voeten</surname>
                  </persName>
                  <idno type="halauthorid">3099278-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Suzanne</forename>
                    <surname>Gisbertz</surname>
                  </persName>
                  <idno type="halauthorid">3099005-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jelle</forename>
                    <surname>Ruurda</surname>
                  </persName>
                  <idno type="halauthorid">3099279-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Richard</forename>
                    <surname>van Hillegersberg</surname>
                  </persName>
                  <idno type="halauthorid">3099280-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xavier</forename>
                    <surname>D’journo</surname>
                  </persName>
                  <idno type="halauthorid">1540516-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jakub</forename>
                    <surname>Chmelo</surname>
                  </persName>
                  <idno type="halauthorid">3099281-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexander</forename>
                    <surname>Phillips</surname>
                  </persName>
                  <idno type="halauthorid">2850439-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Riccardo</forename>
                    <surname>Rosati</surname>
                  </persName>
                  <idno type="halauthorid">803512-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">George</forename>
                    <surname>Hanna</surname>
                  </persName>
                  <idno type="halauthorid">2173122-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nick</forename>
                    <surname>Maynard</surname>
                  </persName>
                  <idno type="halauthorid">3099282-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Wayne</forename>
                    <surname>Hofstetter</surname>
                  </persName>
                  <idno type="halauthorid">3099283-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lorenzo</forename>
                    <surname>Ferri</surname>
                  </persName>
                  <idno type="halauthorid">625818-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mark</forename>
                    <surname>Berge Henegouwen</surname>
                  </persName>
                  <idno type="halauthorid">3099284-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sheraz</forename>
                    <surname>Markar</surname>
                  </persName>
                  <idno type="halauthorid">1004011-0</idno>
                </author>
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                <idno type="halJournalId" status="VALID">10505</idno>
                <idno type="issn">0003-4932</idno>
                <idno type="eissn">1528-1140</idno>
                <title level="j">Annals of Surgery</title>
                <imprint>
                  <publisher>Lippincott, Williams &amp; Wilkins</publisher>
                  <biblScope unit="volume">278</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">701-708</biblScope>
                  <date type="datePub">2023-11-21</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1097/SLA.0000000000006028</idno>
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              <language ident="en">English</language>
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              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
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            <abstract xml:lang="en">
              <p>Objective: To determine the impact of delayed surgical intervention following chemoradiotherapy (CRT) on survival from esophageal cancer. Background: CRT is a core component of multimodality treatment for locally advanced esophageal cancer. The timing of surgery following CRT may influence the probability of performing an oncological resection and the associated operative morbidity. Methods: This was an international, multicenter, cohort study, including patients from 17 centers who received CRT followed by surgery between 2010 and 2020. In the main analysis, patients were divided into 4 groups based upon the interval between CRT and surgery (0–50, 51–100, 101–200, and &gt;200 days) to assess the impact upon 90-day mortality and 5-year overall survival. Multivariable logistic and Cox regression provided hazard ratios (HRs) with 95% CIs adjusted for relevant patient, oncological, and pathologic confounding factors. Results: A total of 2867 patients who underwent esophagectomy after CRT were included. After adjustment for relevant confounders, prolonged interval following CRT was associated with an increased 90-day mortality compared with 0 to 50 days (reference): 51 to 100 days (HR=1.54, 95% CI: 1.04–2.29), 101 to 200 days (HR=2.14, 95% CI: 1.37–3.35), and &gt;200 days (HR=3.06, 95% CI: 1.64–5.69). Similarly, a poorer 5-year overall survival was also observed with prolonged interval following CRT compared with 0 to 50 days (reference): 101 to 200 days (HR=1.41, 95% CI: 1.17–1.70), and &gt;200 days (HR=1.64, 95% CI: 1.24–2.17). Conclusions: Prolonged interval following CRT before esophagectomy is associated with increased 90-day mortality and poorer long-term survival. Further investigation is needed to understand the mechanism that underpins these adverse outcomes observed with a prolonged interval to surgery.</p>
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          <orgName>University of Westminster [London]</orgName>
          <orgName type="acronym">UOW</orgName>
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              <addrLine>309 Regent Street, London W1B 2UW</addrLine>
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