<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04519887</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T09:23:44+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Modeling the impact of urban and hospital eco-exposomes on antibiotic-resistance dynamics in wastewaters</title>
            <author role="aut">
              <persName>
                <forename type="first">Paul</forename>
                <surname>Henriot</surname>
              </persName>
              <email type="md5">8c2da19eb3c871c25a0bae101213b94c</email>
              <email type="domain">protonmail.com</email>
              <idno type="idhal" notation="string">paul-henriot</idno>
              <idno type="idhal" notation="numeric">1181765</idno>
              <idno type="halauthorid" notation="string">2551788-1181765</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9410-0867</idno>
              <affiliation ref="#struct-1090749"/>
              <affiliation ref="#struct-266752"/>
              <affiliation ref="#struct-1051097"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elena</forename>
                <surname>Buelow</surname>
              </persName>
              <idno type="halauthorid">1831263-0</idno>
              <affiliation ref="#struct-185362"/>
              <affiliation ref="#struct-1043049"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabienne</forename>
                <surname>Petit</surname>
              </persName>
              <email type="md5">25d30b1d792ced4a34ba00357290f3e6</email>
              <email type="domain">univ-rouen.fr</email>
              <idno type="idhal" notation="string">fabienne-petit</idno>
              <idno type="idhal" notation="numeric">181334</idno>
              <idno type="halauthorid" notation="string">8133-181334</idno>
              <idno type="IDREF">https://www.idref.fr/07732790X</idno>
              <affiliation ref="#struct-847"/>
              <affiliation ref="#struct-542016"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Cécile</forename>
                <surname>Ploy</surname>
              </persName>
              <email type="md5">4b0dfc482aee9a1167f0b555bbeb9d36</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="numeric">1230392</idno>
              <idno type="halauthorid" notation="string">405437-1230392</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0718-4979</idno>
              <idno type="IDREF">https://www.idref.fr/057866171</idno>
              <idno type="VIAF">https://viaf.org/viaf/173531551</idno>
              <idno type="ISNI">http://isni.org/isni/0000000430841134</idno>
              <affiliation ref="#struct-185362"/>
              <affiliation ref="#struct-1088974"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Dagot</surname>
              </persName>
              <email type="md5">048c7f4b39c6b8e263c8bf0637e14d08</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="numeric">786361</idno>
              <idno type="halauthorid" notation="string">602456-786361</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3632-0420</idno>
              <idno type="IDREF">https://www.idref.fr/033641781</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=24kIQ68AAAAJ</idno>
              <idno type="VIAF">https://viaf.org/viaf/29627845</idno>
              <idno type="ISNI">http://isni.org/isni/0000000121260459</idno>
              <affiliation ref="#struct-185362"/>
              <affiliation ref="#struct-1088974"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lulla</forename>
                <surname>Opatowski</surname>
              </persName>
              <email type="md5">56035a16bd53a1a19737f7ee490e3ff3</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="numeric">996829</idno>
              <idno type="halauthorid" notation="string">686948-996829</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8348-700X</idno>
              <affiliation ref="#struct-1090749"/>
              <affiliation ref="#struct-470602"/>
              <affiliation ref="#struct-1051097"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Nathalie</forename>
                <surname>POTHIER</surname>
              </persName>
              <email type="md5">bbadcf873be535d1d251be6425ad67be</email>
              <email type="domain">cnrs-orleans.fr</email>
            </editor>
            <funder ref="#projanr-24021"/>
            <funder>This study was funded by Agence Nationale Sécurité Sanitaire Alimentaire Nationale (Pandore Project, EST 2017/3 ABR/28). It was also supported directly by internal resources from the French National Institute for Health and Medical Research, the Institut Pasteur, and the University of Versailles–Saint-Quentin-en-Yvelines/University of Paris-Saclay. This study received funding from the French Government's ‘Investissement d'Avenir’ program, Laboratoire d'Excellence ‘Integrative Biology of Emerging Infectious Diseases’ (Grant ANR-10-LABX-62-IBEID).</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-03-27 14:24:07</date>
              <date type="whenModified">2026-03-31 12:57:18</date>
              <date type="whenReleased">2024-03-27 14:24:07</date>
              <date type="whenProduced">2024-05</date>
              <date type="whenEndEmbargoed">2024-03-27</date>
              <ref type="file" target="https://hal.science/hal-04519887v1/document">
                <date notBefore="2024-03-27"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-04519887v1/file/1-s2.0-S0048969724017856-main.pdf" id="file-4523432-3920714">
                <date notBefore="2024-03-27"/>
              </ref>
              <ref type="externalLink" target="https://doi.org/10.1016/j.scitotenv.2024.171643"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="106505">
                <persName>
                  <forename>Nathalie</forename>
                  <surname>POTHIER</surname>
                </persName>
                <email type="md5">bbadcf873be535d1d251be6425ad67be</email>
                <email type="domain">cnrs-orleans.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04519887</idno>
            <idno type="halUri">https://hal.science/hal-04519887</idno>
            <idno type="halBibtex">henriot:hal-04519887</idno>
            <idno type="halRefHtml">&lt;i&gt;Science of the Total Environment&lt;/i&gt;, 2024, 924, pp.171643. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.scitotenv.2024.171643"&gt;&amp;#x27E8;10.1016/j.scitotenv.2024.171643&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Science of the Total Environment, 2024, 924, pp.171643. &amp;#x27E8;10.1016/j.scitotenv.2024.171643&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc-nd/4.0/">CC BY-NC-ND 4.0 - Attribution - Non-commercial use - No Derivative Works<ref corresp="#file-4523432-3920714"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="SHS">Sciences de l'Homme et de la Société</idno>
            <idno type="stamp" n="PASTEUR">Institut Pasteur</idno>
            <idno type="stamp" n="INSU">INSU - Institut National des Sciences de l'Univers</idno>
            <idno type="stamp" n="UNILIM">Université de Limoges</idno>
            <idno type="stamp" n="EPHE">École Pratique des Hautes Études</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="CNAM">Conservatoire National des Arts et Métiers</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="UMR-S1092" corresp="UNILIM">Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques</idno>
            <idno type="stamp" n="CESP" corresp="INSERM">Centre de recherche en Épidémiologie et Santé des Populations</idno>
            <idno type="stamp" n="GIP-BE">GIP Bretagne Environnement</idno>
            <idno type="stamp" n="GEIST" corresp="UNILIM">Génomique, environnement, immunité, thérapeutique</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="METIS_UMR7619" corresp="SORBONNE-UNIVERSITE">Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols</idno>
            <idno type="stamp" n="UVSQ">Université de Versailles Saint-Quentin-en-Yvelines</idno>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="M2C">Production scientifique de l'UMR 6143 - M2C</idno>
            <idno type="stamp" n="UNIROUEN">Université de Rouen Normandie</idno>
            <idno type="stamp" n="UNICAEN">Université de Caen Normandie</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="2IC">Infection et Inflammation</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="MESURS" corresp="CNAM">Modélisation, épidémiologie et surveillance des risques sanitaires </idno>
            <idno type="stamp" n="TEST-DEV">TEST-DEV</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="EPHE-PSL" corresp="PSL">École Pratique des Hautes Études - PSL</idno>
            <idno type="stamp" n="UVSQ-UPSACLAY" corresp="UNIV-PARIS-SACLAY">UVSQ-UPSACLAY</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="GS-LIFE-SCIENCES-HEALTH" corresp="UNIVERSITE-PARIS-SACLAY">Graduate School Life Sciences and Health</idno>
            <idno type="stamp" n="GS-HEALTH-DRUG-SCIENCES">Graduate School Health and Drug Sciences</idno>
            <idno type="stamp" n="GS-SANTE-PUBLIQUE">Graduate School Santé publique</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="OMEGAHEALTH" corresp="UNILIM">OmegaHealth</idno>
            <idno type="stamp" n="HESAM-CNAM" corresp="HESAM">Conservatoire National des Arts et Métiers - Hesam</idno>
            <idno type="stamp" n="HESAM">Hesam</idno>
            <idno type="stamp" n="LABCIS" corresp="UNILIM">Laboratoire des Agroressources, Biomolécules et Chimie pour l’Innovation en Santé</idno>
            <idno type="stamp" n="LTSER-RZA">Collection Infrastructure de Recherche Réseau des Zones Ateliers</idno>
            <idno type="stamp" n="PSACLAY-TEST">Université Paris-Saclay - Collection pour tests</idno>
            <idno type="stamp" n="SUPRA_GEOSCIENCES">Géosciences et co.</idno>
            <idno type="stamp" n="LTSER-ZAS">Collection de la Zone Atelier Seine</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
            <idno type="stamp" n="ANR-ONE-HEALTH">ANR-ONE-HEALTH</idno>
            <idno type="stamp" n="ANR-ONE-HEALTH-DOI" corresp="ANR-ONE-HEALTH">ANR-ONE-HEALTH-DOI</idno>
            <idno type="stamp" n="RESINFIT" corresp="UNILIM">Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques</idno>
          </seriesStmt>
          <notesStmt>
            <note type="commentary">(IF 8.2; Q1)</note>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Modeling the impact of urban and hospital eco-exposomes on antibiotic-resistance dynamics in wastewaters</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Paul</forename>
                    <surname>Henriot</surname>
                  </persName>
                  <email type="md5">8c2da19eb3c871c25a0bae101213b94c</email>
                  <email type="domain">protonmail.com</email>
                  <idno type="idhal" notation="string">paul-henriot</idno>
                  <idno type="idhal" notation="numeric">1181765</idno>
                  <idno type="halauthorid" notation="string">2551788-1181765</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9410-0867</idno>
                  <affiliation ref="#struct-1090749"/>
                  <affiliation ref="#struct-266752"/>
                  <affiliation ref="#struct-1051097"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elena</forename>
                    <surname>Buelow</surname>
                  </persName>
                  <idno type="halauthorid">1831263-0</idno>
                  <affiliation ref="#struct-185362"/>
                  <affiliation ref="#struct-1043049"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabienne</forename>
                    <surname>Petit</surname>
                  </persName>
                  <email type="md5">25d30b1d792ced4a34ba00357290f3e6</email>
                  <email type="domain">univ-rouen.fr</email>
                  <idno type="idhal" notation="string">fabienne-petit</idno>
                  <idno type="idhal" notation="numeric">181334</idno>
                  <idno type="halauthorid" notation="string">8133-181334</idno>
                  <idno type="IDREF">https://www.idref.fr/07732790X</idno>
                  <affiliation ref="#struct-847"/>
                  <affiliation ref="#struct-542016"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Cécile</forename>
                    <surname>Ploy</surname>
                  </persName>
                  <email type="md5">4b0dfc482aee9a1167f0b555bbeb9d36</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="numeric">1230392</idno>
                  <idno type="halauthorid" notation="string">405437-1230392</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0718-4979</idno>
                  <idno type="IDREF">https://www.idref.fr/057866171</idno>
                  <idno type="VIAF">https://viaf.org/viaf/173531551</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000430841134</idno>
                  <affiliation ref="#struct-185362"/>
                  <affiliation ref="#struct-1088974"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Dagot</surname>
                  </persName>
                  <email type="md5">048c7f4b39c6b8e263c8bf0637e14d08</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="numeric">786361</idno>
                  <idno type="halauthorid" notation="string">602456-786361</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3632-0420</idno>
                  <idno type="IDREF">https://www.idref.fr/033641781</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=24kIQ68AAAAJ</idno>
                  <idno type="VIAF">https://viaf.org/viaf/29627845</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000121260459</idno>
                  <affiliation ref="#struct-185362"/>
                  <affiliation ref="#struct-1088974"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lulla</forename>
                    <surname>Opatowski</surname>
                  </persName>
                  <email type="md5">56035a16bd53a1a19737f7ee490e3ff3</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="numeric">996829</idno>
                  <idno type="halauthorid" notation="string">686948-996829</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8348-700X</idno>
                  <affiliation ref="#struct-1090749"/>
                  <affiliation ref="#struct-470602"/>
                  <affiliation ref="#struct-1051097"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">18830</idno>
                <idno type="issn">0048-9697</idno>
                <idno type="eissn">1879-1026</idno>
                <title level="j">Science of the Total Environment</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">924</biblScope>
                  <biblScope unit="pp">171643</biblScope>
                  <date type="datePub">2024-05</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.scitotenv.2024.171643</idno>
              <idno type="pubmed">38471588</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Mathematical modeling</term>
                <term xml:lang="en">Antibiotic resistance</term>
                <term xml:lang="en">Effluents</term>
                <term xml:lang="en">Dynamics</term>
                <term xml:lang="en">Eco-exposome</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.mp">Life Sciences [q-bio]/Microbiology and Parasitology</classCode>
              <classCode scheme="halDomain" n="shs.envir">Humanities and Social Sciences/Environmental studies</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART.ARTREV">Journal articles - Review article</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The emergence and selection of antibiotic resistance is a major public health problem worldwide. The presence of antibiotic-resistant bacteria (ARBs) in natural and anthropogenic environments threatens the sustainability of efforts to reduce resistance in human and animal populations. Here, we use mathematical modeling of the selective effect of antibiotics and contaminants on the dynamics of bacterial resistance in water to analyze longitudinal spatio-temporal data collected in hospital and urban wastewater between 2012 and 2015. Samples were collected monthly during the study period at four different sites in Haute-Savoie, France: hospital and urban wastewater, before and after water treatment plants. Three different categories of exposure variables were collected simultaneously: 1) heavy metals, 2) antibiotics and 3) surfactants for a total of 13 drugs/molecules; in parallel to the normalized abundance of 88 individual genes and mobile genetic elements, mostly conferring resistance to antibiotics. A simple hypothesis-driven model describing weekly antibiotic resistance gene (ARG) dynamics was proposed to fit the available data, assuming that normalized gene abundance is proportional to antibiotic resistant bacteria (ARB) populations in water. The detected compounds were found to influence the dynamics of 17 genes found at multiple sites. While mercury and vancomycin were associated with increased ARG and affected the dynamics of 10 and 12 identified genes respectively, surfactants antagonistically affected the dynamics of three genes. The models proposed here make it possible to analyze the relationship between the persistence of resistance genes in the aquatic environment and specific compounds associated with human activities from longitudinal data. Our analysis of French data over 2012–2015 identified mercury and vancomycin as co-selectors for some ARGs.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1090749" status="VALID">
          <idno type="RNSR">200818134F</idno>
          <orgName>Epidémiologie et modélisation de la résistance aux antimicrobiens - Epidemiology and modelling of antibacterial evasion</orgName>
          <orgName type="acronym">EMAE</orgName>
          <date type="start">2021-07-21</date>
          <desc>
            <address>
              <addrLine>25-28 rue du Docteur Roux, 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://research.pasteur.fr/fr/team/epidemiology-and-modelling-of-bacterial-escape-to-antimicrobials/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300027" type="direct"/>
            <relation active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-266752" status="VALID">
          <idno type="IdRef">181157772</idno>
          <idno type="RNSR">201119409D</idno>
          <idno type="ROR">https://ror.org/00fmavj37</idno>
          <orgName>Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires</orgName>
          <orgName type="acronym">MESuRS</orgName>
          <desc>
            <address>
              <addrLine>292 rue Saint-Martin F-75141 Paris Cédex 03</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://mesurs.cnam.fr/</ref>
          </desc>
          <listRelation>
            <relation name="EA4628" active="#struct-300351" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1051097" status="VALID">
          <idno type="IdRef">156182254</idno>
          <idno type="ISNI">0000 0004 0638 6872 </idno>
          <idno type="RNSR">201019083D</idno>
          <idno type="ROR">https://ror.org/01ed4t417</idno>
          <orgName>Centre de recherche en épidémiologie et santé des populations</orgName>
          <orgName type="acronym">CESP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR U1018" active="#struct-81173" type="direct"/>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-300153" type="direct"/>
            <relation active="#struct-1066727" type="indirect"/>
            <relation name="U1018" active="#struct-303623" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-185362" status="OLD">
          <idno type="IdRef">188400877</idno>
          <idno type="RNSR">201220172D</idno>
          <orgName>Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques</orgName>
          <orgName type="acronym">RESINFIT</orgName>
          <date type="start">2012-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Limoges - Faculté de Médecine - 2 rue du Docteur Marcland 87025 Limoges Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unilim.fr/recherche/laboratoires/geist/anti-infectieux-supports-moleculaires-des-resistances-et-innovations-therapeutiques-resinfit/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300906" type="direct"/>
            <relation name="U1092" active="#struct-303623" type="direct"/>
            <relation active="#struct-526218" type="direct"/>
            <relation active="#struct-5928" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1043049" status="VALID">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525</orgName>
          <orgName type="acronym">TIMC</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
            <relation active="#struct-1043329" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-847" status="VALID">
          <idno type="IdRef">184390478</idno>
          <idno type="RNSR">200012210B</idno>
          <idno type="ROR">https://ror.org/05k1a6w82</idno>
          <idno type="Wikidata">Q51783493</idno>
          <orgName>Morphodynamique Continentale et Côtière</orgName>
          <orgName type="acronym">M2C</orgName>
          <date type="start">1996-01-01</date>
          <desc>
            <address>
              <addrLine>24 rue des Tilleuls 14000 Caen</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicaen.fr/m2c</ref>
          </desc>
          <listRelation>
            <relation active="#struct-7127" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation active="#struct-300045" type="direct"/>
            <relation active="#struct-300318" type="direct"/>
            <relation name="UMR6143" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-542016" status="VALID">
          <idno type="IdRef">192758012</idno>
          <idno type="ISNI">0000000104264677</idno>
          <idno type="RNSR">199712664H</idno>
          <idno type="ROR">https://ror.org/0229z0679</idno>
          <orgName>Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols</orgName>
          <orgName type="acronym">METIS</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>Sorbonne Université, Case courrier 105, 4 place Jussieu, 75005 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.metis.upmc.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-110691" type="direct"/>
            <relation active="#struct-564132" type="indirect"/>
            <relation name="UMR7619" active="#struct-300045" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
            <relation name="UMR7619" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1088974" status="VALID">
          <idno type="IdRef">188400877</idno>
          <idno type="RNSR">201220172D</idno>
          <idno type="ROR">https://ror.org/0458p8g61</idno>
          <idno type="Wikidata">Q121599448</idno>
          <orgName>Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques</orgName>
          <orgName type="acronym">RESINFIT</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine - 2 rue du Docteur Marcland 87025 Limoges Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unilim.fr/resinfit/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300906" type="direct"/>
            <relation name="UMR Inserm 1092" active="#struct-303623" type="direct"/>
            <relation active="#struct-1088917" type="direct"/>
            <relation active="#struct-5928" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-470602" status="VALID">
          <idno type="IdRef">192721984</idno>
          <idno type="RNSR">201521272L</idno>
          <idno type="ROR">https://ror.org/021sh3243</idno>
          <orgName>Infection et inflammation</orgName>
          <orgName type="acronym">2I</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Batiment Simone Veil - 2 avenue de la source de la Bièvre 78180 Montigny-le-Bretonneux</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR1173" active="#struct-81173" type="direct"/>
            <relation name="U1173" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300027" status="VALID">
          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <idno type="ROR">https://ror.org/0495fxg12</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <orgName type="acronym">IP</orgName>
          <date type="start">1887-06-04</date>
          <desc>
            <address>
              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300351" status="VALID">
          <idno type="IdRef">027404978</idno>
          <idno type="ISNI">0000000121690459</idno>
          <idno type="ROR">https://ror.org/0175hh227</idno>
          <orgName>Conservatoire National des Arts et Métiers [Cnam]</orgName>
          <orgName type="acronym">Cnam</orgName>
          <desc>
            <address>
              <addrLine>292 Rue Saint-Martin, 75003 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnam.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-81173" status="VALID">
          <idno type="IdRef">03082057X</idno>
          <idno type="ISNI">0000 0001 2323 0229 </idno>
          <idno type="ROR">https://ror.org/03mkjjy25</idno>
          <orgName>Université de Versailles Saint-Quentin-en-Yvelines</orgName>
          <orgName type="acronym">UVSQ</orgName>
          <date type="start">1991-07-22</date>
          <desc>
            <address>
              <addrLine>55 avenue de Paris - 78035 Versailles cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.uvsq.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300153" status="VALID">
          <idno type="ROR">https://ror.org/05n7yzd13</idno>
          <orgName>Hôpital Paul Brousse</orgName>
          <desc>
            <address>
              <addrLine>12 Avenue Paul Vaillant Couturier, 94800 Villejuif</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1066727" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1066727" status="VALID">
          <orgName>AP-HP. Université Paris Saclay</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.aphp.fr/groupes-hospitaliers-de-lap-hp</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300906" status="VALID">
          <idno type="ROR">https://ror.org/01tc2d264</idno>
          <orgName>CHU Limoges</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-526218" status="VALID">
          <idno type="IdRef">224565699</idno>
          <orgName>Institut Génomique, Environnement, Immunité, Santé, Thérapeutique</orgName>
          <orgName type="acronym">GEIST</orgName>
          <date type="start">2018-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Limoges - Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unilim.fr/recherche/laboratoires/geist/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-5928" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-5928" status="VALID">
          <idno type="IdRef">026403315</idno>
          <idno type="ISNI">0000000121654861</idno>
          <idno type="ROR">https://ror.org/02cp04407</idno>
          <orgName>Université de Limoges</orgName>
          <orgName type="acronym">UNILIM</orgName>
          <date type="start">1968-10-01</date>
          <desc>
            <address>
              <addrLine>33 rue François Mitterrand BP23204 87032 Limoges</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unilim.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1043329" status="VALID">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-7127" status="VALID">
          <idno type="IdRef">026403064</idno>
          <idno type="ISNI">0000000121864076</idno>
          <idno type="ROR">https://ror.org/051kpcy16</idno>
          <orgName>Université de Caen Normandie</orgName>
          <orgName type="acronym">UNICAEN</orgName>
          <date type="start">1432-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicaen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300045" status="VALID">
          <idno type="IdRef">029349265</idno>
          <idno type="ISNI">0000 0001 2154 1736</idno>
          <idno type="ROR">https://ror.org/04kdfz702</idno>
          <idno type="Wikidata">Q3152437</idno>
          <orgName>Institut national des sciences de l'Univers</orgName>
          <orgName type="acronym">INSU - CNRS</orgName>
          <date type="start">2007-04-19</date>
          <desc>
            <address>
              <addrLine>INSU-CNRS3 rue Michel-Ange, 75794 Paris Cedex 16</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.insu.cnrs.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300318" status="VALID">
          <idno type="IdRef">026403919</idno>
          <idno type="ISNI">0000000121083034</idno>
          <idno type="ROR">https://ror.org/03nhjew95</idno>
          <orgName>Université de Rouen Normandie</orgName>
          <orgName type="acronym">UNIROUEN</orgName>
          <date type="start">1966-01-01</date>
          <desc>
            <address>
              <addrLine>1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-rouen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-110691" status="VALID">
          <idno type="IdRef">026375478</idno>
          <idno type="ISNI">0000000121955365</idno>
          <idno type="ROR">https://ror.org/046b3cj80</idno>
          <orgName>École Pratique des Hautes Études</orgName>
          <orgName type="acronym">EPHE</orgName>
          <date type="start">1868-01-01</date>
          <desc>
            <address>
              <addrLine>4-14 Rue Ferrus, 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ephe.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-564132" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-564132" status="VALID">
          <idno type="IdRef">241597595</idno>
          <idno type="ISNI">0000 0004 1784 3645</idno>
          <idno type="ROR">https://ror.org/013cjyk83</idno>
          <orgName>Université Paris Sciences et Lettres</orgName>
          <orgName type="acronym">PSL</orgName>
          <desc>
            <address>
              <addrLine>60 rue Mazarine 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.psl.eu/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1088917" status="VALID">
          <idno type="IdRef">224565699</idno>
          <orgName>OmégaHealth</orgName>
          <orgName type="acronym">ΩHealth</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unilim.fr/recherche/laboratoires/omegahealth/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-5928" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-24021" status="VALID">
          <idno type="anr">ANR-10-LABX-0062</idno>
          <orgName>IBEID</orgName>
          <desc>Integrative Biology of Emerging Infectious Diseases</desc>
          <date type="start">2010</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>