Article Dans Une Revue Veterinary Research Année : 2022

An inactivated novel chimeric FAdV-4 containing fiber of FAdV-8b provides full protection against hepatitis-hydropericardium syndrome and inclusion body hepatitis

Baiyu Wang
  • Fonction : Auteur
Mingzhen Song
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Congcong Song
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Shiyi Zhao
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Panpan Yang
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Qilong Qiao
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Yanfang Cong
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Yanling Wang
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Zeng Wang
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Jun Zhao
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Résumé

AbstractFowl adenovirus serotype 4 (FAdV-4) and FAdV-8b are causative agents of hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH), respectively. HHS and IBH co-infections were often reported in clinical, yet there are no commercially available bivalent vaccines for prevention and control of both FAdV-4 and -8b. In the present study, a chimeric FAdV-4 was firstly generated by substituting fiber-1 of FAdV-4 with fiber of FAdV-8b. The chimeric virus, rFAdV-4-fiber/8b, exhibited similar replication ability in vitro and pathogenicity in vivo to the parental wild type FAdV-4. A single dosage of vaccination with the inactivated rFAdV-4-fiber/8b induced high antibody titers against fiber-2 of FAdV-4 and fiber of FAdV-8b and provided full protection against FAdV-4 and -8b challenge. These results demonstrated that fiber of FAdV-8b could replace the role of fiber-1 of FAdV-4 in the process of viral infection, and rFAdV-4-fiber/8b could be used to make a potential bivalent vaccine for the control and prevention of HHS and IBH.

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hal-04519473 , version 1 (25-03-2024)

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Baiyu Wang, Mingzhen Song, Congcong Song, Shiyi Zhao, Panpan Yang, et al.. An inactivated novel chimeric FAdV-4 containing fiber of FAdV-8b provides full protection against hepatitis-hydropericardium syndrome and inclusion body hepatitis. Veterinary Research, 2022, 53 (1), pp.75. ⟨10.1186/s13567-022-01093-2⟩. ⟨hal-04519473⟩

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