Ligand impact on reactive oxygen species generation of Au10 and Au25 nanoclusters upon one- and two-photon excitation - Archive ouverte HAL Access content directly
Journal Articles Communications Chemistry Year : 2023

Ligand impact on reactive oxygen species generation of Au10 and Au25 nanoclusters upon one- and two-photon excitation

Martina Perić Bakulić
Issan Zhang
  • Function : Author
Hao Yuan
Dipankar Bain
Željka Sanader Maršić
  • Function : Author
Vlasta Bonačić-Koutecký
  • Function : Author
Dusica Maysinger

Abstract

Abstract In photodynamic therapy (PDT), light-sensitive photosensitizers produce reactive oxygen species (ROS) after irradiation in the presence of oxygen. Atomically-precise thiolate-protected gold nanoclusters are molecule-like nanostructures with discrete energy levels presenting long lifetimes, surface biofunctionality, and strong near-infrared excitation ideal for ROS generation in PDT. We directly compare thiolate-gold macromolecular complexes (Au 10 ) and atomically-precise gold nanoclusters (Au 25 ), and investigate the influence of ligands on their photoexcitation. With the ability of atomically-precise nanochemistry, we produce Au 10 SG 10 , Au 10 AcCys 10 , Au 25 SG 18 , and Au 25 AcCys 18 (SG: glutathione; AcCys: N-acetyl-cysteine) fully characterized by high-resolution mass spectrometry. Our theoretical investigation reveals key factors (energetics of excited states and structural influence of surface ligands) and their relative importance in singlet oxygen formation upon one- and two-photon excitation. Finally, we explore ROS generation by gold nanoclusters in living cells with one- and two-photon excitation. Our study presents in-depth analyses of events within gold nanoclusters when photo-excited both in the linear and nonlinear optical regimes, and possible biological consequences in cells.
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Dates and versions

hal-04517510 , version 1 (22-03-2024)

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Cite

Hussein Fakhouri, Martina Perić Bakulić, Issan Zhang, Hao Yuan, Dipankar Bain, et al.. Ligand impact on reactive oxygen species generation of Au10 and Au25 nanoclusters upon one- and two-photon excitation. Communications Chemistry, 2023, 6 (1), pp.97. ⟨10.1038/s42004-023-00895-5⟩. ⟨hal-04517510⟩
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