Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life - Archive ouverte HAL Access content directly
Journal Articles Philosophical Transactions of the Royal Society B: Biological Sciences Year : 2024

Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life

Luc Dantan
Eve Toulza

Abstract

The Pacific oyster Crassostrea gigas lives in microbe-rich marine coastal systems subjected to rapid environmental changes. It harbours a diversified and fluctuating microbiota that cohabits with immune cells expressing a diversified immune gene repertoire. In the early stages of oyster development, just after fertilization, the microbiota plays a key role in educating the immune system. Exposure to a rich microbial environment at the larval stage leads to an increase in immune competence throughout the life of the oyster, conferring a better protection against pathogenic infections at later juvenile/adult stages. This beneficial effect, which is intergenerational, is associated with epigenetic remodelling. At juvenile stages, the educated immune system participates in the control of the homeostasis. In particular, the microbiota is fine-tuned by oyster antimicrobial peptides acting through specific and synergistic effects. However, this balance is fragile, as illustrated by the Pacific Oyster Mortality Syndrome, a disease causing mass mortalities in oysters worldwide. In this disease, the weakening of oyster immune defences by OsHV-1 µVar virus induces a dysbiosis leading to fatal sepsis. This review illustrates the continuous interaction between the highly diversified oyster immune system and its dynamic microbiota throughout its life, and the importance of this cross-talk for oyster health. This article is part of the theme issue ‘Sculpting the microbiome: how host factors determine and respond to microbial colonization’.
Fichier principal
Vignette du fichier
Destoumieux-2024-PhilTransRSocB-Cross-talk.pdf (690.79 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-04515139 , version 1 (21-03-2024)

Identifiers

Cite

Delphine Destoumieux-Garzón, Caroline Montagnani, Luc Dantan, Noémie de San Nicolas, Marie-Agnès Travers, et al.. Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life. Philosophical Transactions of the Royal Society B: Biological Sciences, 2024, 379 (1901), ⟨10.1098/rstb.2023.0065⟩. ⟨hal-04515139⟩
1 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More