Prevalence of chronic pulmonary aspergillosis in two Tuberculosis treatment clinics in Lagos, Nigeria: a prospective longitudinal study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Open Forum Infectious Diseases Année : 2024

Prevalence of chronic pulmonary aspergillosis in two Tuberculosis treatment clinics in Lagos, Nigeria: a prospective longitudinal study

Adeyinka a Davies
Abiola O Adekoya
  • Fonction : Auteur
Iriagbonse I Osaigbovo
Olubunmi Osinupebi
  • Fonction : Auteur
Rita O Oladele

Résumé

Abstract Background Chronic pulmonary aspergillosis (CPA) is an underrecognized but common complication of pulmonary tuberculosis (TB). In Nigeria, a TB-endemic country, there is currently no provision to monitor the development of CPA in patients treated for TB. This study determined the prevalence and incidence of CPA in Lagos, Nigeria. Methods A prospective longitudinal study of patients previously managed for TB was conducted between June 2021 and May 2022. The study cohorts were assessed at three monthly intervals with the following parameters collected: sociodemographic data, chest x-ray findings, sputum for fungal culture, and venous blood for Aspergillus IgG estimation. CPA cases were determined using the case definition for resource-constrained countries. Descriptive and inferential statistics were employed and significance was set at a probability of 5% (p<0.05). Results Of 141 patients recruited, 79 (56.0%) belonged to retreatment TB and 62 (44.0%) were post-TB treated patients. The median (interquartile range) age was 40 (30-52) years, with a male-to-female ratio of 1.1:1. Ninety-seven patients (69%) had a GeneXpert test done, of which, 63/97 (64.9%) were GeneXpert negative. Cough was the commonest symptom, with 15 (11%) having haemoptysis. The rate of CPA increased steadily as the study progressed: 44 (31.2%) at commencement, 45 (34.9%) at three months, 49 (42.6%) at six months, and 51 (54.3%) at nine months. Thus, the overall prevalence of CPA was 49.7% and the incidence was 6.1%. Conclusion CPA is common in Nigeria and its true burden may still be underestimated. Increased awareness of CPA as a post-TB lung disease is advocated. Evaluation for CPA should be incorporated in patients’ work-up for TB

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Dates et versions

hal-04512860 , version 1 (20-03-2024)

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Adeyinka a Davies, Abiola O Adekoya, Oluwaseyi J Balogun, Iriagbonse I Osaigbovo, Augustina Nwosu, et al.. Prevalence of chronic pulmonary aspergillosis in two Tuberculosis treatment clinics in Lagos, Nigeria: a prospective longitudinal study. Open Forum Infectious Diseases, 2024, Open Forum Infectious Diseases, ⟨10.1093/ofid/ofae090⟩. ⟨hal-04512860⟩
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