European consensus-based interdisciplinary guideline for diagnosis, treatment and prevention of actinic keratoses, epithelial UV-induced dysplasia and field cancerization on behalf of European Association of Dermato-Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of the European Academy of Dermatology and Venereology Année : 2024

European consensus-based interdisciplinary guideline for diagnosis, treatment and prevention of actinic keratoses, epithelial UV-induced dysplasia and field cancerization on behalf of European Association of Dermato-Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes)

Lidija Kandolf
Željko Mijušković
  • Fonction : Auteur
Ketty Peris
Josep Malvehy
  • Fonction : Auteur
Susana Puig
Klara Mosterd
Nicole Kelleners Smeeths
  • Fonction : Auteur
Markus V. Heppt
Carola Berking
  • Fonction : Auteur
Maria Concetta Fargnoli
Petr Arenberger
Matilda Bylaite-Bučinskiene
  • Fonction : Auteur
Veronique del Marmol
  • Fonction : Auteur
Thomas Dirschka
  • Fonction : Auteur
Brigitte Dreno
Ana-Maria Forsea
Catherine A. Harwood
  • Fonction : Auteur
Axel Hauschild
  • Fonction : Auteur
Ida Marie Heerfordt
Roland Kauffman
Aimilios Lallas
Celeste Lebbe
  • Fonction : Auteur
Ulrike Leiter
Claus Garbe
  • Fonction : Auteur
Caterina Longo
Giovanni Pellacani
Mirna Šitum
  • Fonction : Auteur
Eggert Stockfleth
  • Fonction : Auteur
Carmen Salavastru
  • Fonction : Auteur
Alexander Stratigos
  • Fonction : Auteur
Iris Zalaudek
  • Fonction : Auteur

Résumé

A collaboration of multidisciplinary experts from the European Association of Dermato-Oncology, the European Dermatology Forum, the European Academy of Dermatology and Venereology, and the European Union of Medical Specialists was formed to develop European recommendations on AK diagnosis and treatment, based on current literature and expert consensus. This guideline addresses the epidemiology, diagnostics, risk stratification and treatments in immunocompetent as well as immunosuppressed patients. Actinic keratoses (AK) are potential precursors of cutaneous squamous cell carcinoma (cSCC) and display typical histopathologic and immunohistochemical features of this malignancy in an early stage. They can develop into cSSC in situ and become invasive in a low percentage of cases. AK is the most frequent neoplasia in white populations, frequently occurring within a cancerous field induced by ultraviolet radiation. Since it cannot be predicted, which lesion will progress to cSCC and when treatment is usually recommended. The diagnosis of AK and field cancerization is made by clinical examination. Dermatoscopy, confocal microscopy, optical coherence tomography or line-field confocal-OCT can help in the differential diagnosis of AK and other skin neoplasms. A biopsy is indicated in clinically and/or dermatoscopically suspicious and/or treatment-refractory lesions. The choice of treatment depends on patients and lesion characteristics. For single non-hyperkeratotic lesions, the treatment can be started upon patient s request with destructive treatments or topical treatments. For multiple lesions, field cancerization treatment is advised with topical treatments and photodynamic therapy. Preventive measures such as sun protection, self-examination and repeated field cancerization treatments of previously affected skin areas in high-risk patients are advised.
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Dates et versions

hal-04510894 , version 1 (19-03-2024)

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Lidija Kandolf, Željko Mijušković, Ketty Peris, Josep Malvehy, Susana Puig, et al.. European consensus-based interdisciplinary guideline for diagnosis, treatment and prevention of actinic keratoses, epithelial UV-induced dysplasia and field cancerization on behalf of European Association of Dermato-Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes). Journal of the European Academy of Dermatology and Venereology, 2024, ⟨10.1111/jdv.19897⟩. ⟨hal-04510894⟩
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