Immunosuppressive Ability of Trichinella spiralis Adults Can Ameliorate Type 2 Inflammation in a Murine Allergy Model - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Infectious Diseases Année : 2024

Immunosuppressive Ability of Trichinella spiralis Adults Can Ameliorate Type 2 Inflammation in a Murine Allergy Model

Wenjie Shi
Qinwei Xu
  • Fonction : Auteur
Yan Liu
  • Fonction : Auteur
Zhili Hao
  • Fonction : Auteur
Yue Liang
  • Fonction : Auteur
Xihuo You
  • Fonction : Auteur
Mingyuan Liu
  • Fonction : Auteur
Xiaolei Liu
  • Fonction : Auteur correspondant
Ning Xu
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Résumé

Abstract Background There is an increase in the global incidence of allergies. The hygiene hypothesis and the old friend hypothesis reveal that helminths are associated with the prevalence of allergic diseases. The therapeutic potential of Trichinella spiralis is recognized; however, the stage at which it exerts its immunomodulatory effect is unclear. Methods We evaluated the differentiation of bone marrow–derived macrophages stimulated with T spiralis excretory-secretory products. Based on an ovalbumin-induced murine model, T spiralis was introduced during 3 allergy phases. Cytokine levels and immune cell subsets in the lung, spleen, and peritoneal cavity were assessed. Results We found that T spiralis infection reduced lung inflammation, increased anti-inflammatory cytokines, and decreased Th2 cytokines and alarms. Recruitment of eosinophils, CD11b+ dendritic cells, and interstitial macrophages to the lung was significantly suppressed, whereas Treg cells and alternatively activated macrophages increased in T spiralis infection groups vs the ovalbumin group. Notably, when T spiralis was infected prior to ovalbumin challenge, intestinal adults promoted proportions of CD103+ dendritic cells and alveolar macrophages. Conclusions T spiralis strongly suppressed type 2 inflammation, and adults maintained lung immune homeostasis.
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Dates et versions

hal-04505357 , version 1 (14-03-2024)

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Wenjie Shi, Qinwei Xu, Yan Liu, Zhili Hao, Yue Liang, et al.. Immunosuppressive Ability of Trichinella spiralis Adults Can Ameliorate Type 2 Inflammation in a Murine Allergy Model. Journal of Infectious Diseases, 2024, 229 (4), pp.1215-1228. ⟨10.1093/infdis/jiad518⟩. ⟨hal-04505357⟩
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