Objectives Pressure ulcers (PUs) are a common and avoidable condition among residents of nursing homes, and their consequences are severe. Reliable and simple identification of high-risk residents is a major challenge for prevention. Available tools like the Braden and Norton scale have imperfect predictive performance. The objective is to predict the occurrence of PUs in nursing home residents from electronic health record (EHR) data. Design Longitudinal retrospective nested case-control study. Setting and Participants EHR database of French nursing homes from 2013 to 2022. Methods Residents who suffered from PUs were cases and those who did not were controls. For cases, we analyzed the data available in their EHR 1 month before the occurrence of the first PU. For controls, we used available data 1 month before an index date adjusted on the delays of PU onset. We conducted a Bayesian network (BN) analysis, an explainable machine learning method, using 136 input variables of potential medical interest determined with experts. To validate the model, we used scores, features selection, and explainability tools such as Shapley values. Results Among 58,368 residents analyzed, 29% suffered from PUs during their stay. The obtained BN model predicts the occurrence of a PU at a 1-month horizon with a sensitivity of 0.94 (±0.01), a precision of 0.32 (±0.01) and an area under the curve of 0.69 (±0.02). It selects 3 variables: length of stay, delay since last hospitalization, and dependence for transfer. This BN model is suitable and simpler than models provided by other machine learning methods. Conclusions and Implications One-month prediction for incident PU is possible in nursing home residents from their EHR data. The study paves the way for the development of a predictive tool fueled by routinely collected data that do not require additional work from health care professionals, thereby opening a new preventive strategy for PUs.