In this paper we present a numerical discretization of the coupled elasto-acoustic wave propagation problem based on a Discontinuous Galerkin Spectral Element (DGSE) approach in a three-dimensional setting. The unknowns of the coupled problem are the displacement field and the velocity potential, in the elastic and the acoustic domains, respectively, thereby resulting in a symmetric formulation. After stating the main theoretical results, we assess the performance of the method by convergence tests carried out on both matching and non-matching grids, and we simulate realistic scenarios where elasto-acoustic coupling occurs. In particular, we consider the case of Scholte waves, the scattering of elastic waves by an underground acoustic cavity, and a problem of marine seismic exploration. Numerical simulations are carried out by means of the code SPEED, available at http://speed.mox.polimi.it.