Influence of the Optimisation Approach on the Determination of Operating Conditions of Batch Global Syntheses
Résumé
Optimisation of fine chemistry syntheses is often restricted to a dissociated approach of the process, lying in the separated determination of optimal conditions of each operating step. In this paper, an optimisation framework integrating a global optimisation approach is presented. Based on an the accurate modelling of reaction-separation processes linked with an efficient SQP method, this framework allows optimising various fine chemistry syntheses. The purpose of the present paper focuses on the validation and the application of this framework. Thus, compared with a classical approach, the application to a propylene glycol synthesis highlights the benefits and the limits of the proposed methodology.
Domaines
Génie chimique
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