Along the coast of northwestern Alaska, architectural wood remains are well preserved in the Birnirk and Thule coastal sites of the early 2nd millennium CE. These structural wood elements are unique archives for documenting climatic variations and cultural transformations during this key development period of Inuit culture. Along this treeless Arctic coast, driftwood accumulates from the subarctic forests of interior Alaska. Except for northwestern Alaska, regional tree-ring chronologies are too short (at best 350–400 years) to successfully date archaeological wood remains from Birnirk and Thule coastal sites using conventional dendrochronology. This paper examines the potential of tree-ring derived δ18O signal to annually date eight architectural wood samples from the Rising Whale (KTZ-304) site at Cape Espenberg, northwestern Alaska. We developed a δ18O master chronology, covering the period 935–1157 CE, using five wood samples from the KTZ-304 site. Blind isotope cross-dating of individual series belonging to this δ18O master chronology (one against the other four) showed conclusive dating and a very strong coherence of the isotopic signal. We, then, used the δ18O master chronology to cross-date three other wood samples for which we knew, from previous 14C wiggle-matching procedure, the first measured ring to be in this time interval, within a ± 18 to 30-year precision. Oxygen isotope dendrochronology provided a plausible date for one of the samples (the first measured ring at 1073 CE). This preliminary study encourages us to acquire additional data to extend in time and strengthen the δ18O master chronology of northwestern Alaska (NWAK18O) and help refine our understanding of climate and culture change during the 2nd millennium CE.