Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1 - Archive ouverte HAL Access content directly
Journal Articles Translational Psychiatry Year : 2024

Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1

Luana Spano (1) , Cynthia Marie-Claire (1) , Ophélia Godin (2, 3) , Apolline Lebras (1) , Cindie Courtin (1) , Jean-Louis Laplanche (1, 4, 5) , Marion Leboyer (6, 2, 3) , Bruno Aouizerate (2, 7, 8) , Antoine Lefrere (2, 9) , Raoul Belzeaux (10, 2, 11) , Philippe Courtet (12, 13, 2) , Emilie Olié (12, 13, 2) , Caroline Dubertret (2, 14, 15, 5) , Raymund Schwan (2, 16, 17) , Valérie Aubin (2, 18) , Paul Roux (19, 2, 20) , Mircea Polosan (2, 21, 22) , Ludovic Samalin (2, 23, 24) , Emmanuel Haffen (25, 2, 26) , B. Etain (1, 5, 2, 4) , E. Olié (2, 12, 13) , M. Leboyer , E. Haffen , P. Llorca , V. Barteau , S. Bensalem , O. Godin , H. Laouamri , K. Souryis , S. Hotier , A. Pelletier , N. Drancourt , J. Sanchez , E. Saliou , C. Hebbache , J. Petrucci , L. Willaume , E. Bourdin , F. Bellivier , B. Etain , V. Hennion , E. Marlinge , P. Lebard , B. Antoniol , A. Desage , S. Gard , A. Jutant , K. Mbailara , I. Minois , L. Zanouy , C. Abettan , L. Bardin , A. Cazals , P. Courtet , B. Deffinis , D. Ducasse , M. Gachet , A. Henrion , E. Martinerie , F. Molière , B. Noisette , E. Olié , G. Tarquini , J. Azorin , R. Belzeaux , N. Correard , J. Consoloni , F. Groppi , L. Lescalier , J. Montant , M. Rebattu , N. Viglianese , R. Cohen , J. Kahn , M. Milazzo , O. Wajsbrot-Elgrabli , T. Bougerol , B. Fredembach , Q. Denoual , A. Bertrand , A. Pouchon , M. Polosan , L. Brehon , G. Bony , L. Durand , V. Feuga , N. Kayser , C. Passerieux , P. Roux , V. Aubin , I. Cussac , M. Dupont , J. Loftus , I. Medecin , C. Dubertret , N. Mazer , C. Portalier , C. Scognamiglio , A. Bing , P. Laurent , C. Beal , O. Blanc , T. Bonnet , D. Lacelle , P. Llorca , M. Mennetrier , L. Samalin , M. Vayssié , Frank Bellivier (1, 2, 27) , Bruno Etain (1, 28, 5, 2)
1 OPTeN (UMR_S 1144 / U1144) - Optimisation thérapeutique en Neuropsychopharmacologie
2 Fondation FondaMental [Créteil]
3 IMRB - Institut Mondor de Recherche Biomédicale
4 Hôpital Lariboisière-Fernand-Widal [APHP]
5 GHU AP-HP Nord - Université Paris Cité
6 CHU Henri Mondor [Créteil]
7 Centre hospitalier Charles Perrens [Bordeaux]
8 NutriNeuro - Nutrition et Neurobiologie intégrée
9 APHM - Assistance Publique - Hôpitaux de Marseille
10 INT - Institut de Neurosciences de la Timone
11 UM - Université de Montpellier
12 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
13 IGF - Institut de Génomique Fonctionnelle
14 Hôpital Louis Mourier - AP-HP [Colombes]
15 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
16 CPN - Centre Psychothérapique de Nancy [Laxou]
17 IADI - Imagerie Adaptative Diagnostique et Interventionnelle
18 Centre Hospitalier Princesse Grace
19 CESP - Centre de recherche en épidémiologie et santé des populations
20 CHV - Centre Hospitalier de Versailles André Mignot
21 GIN - [GIN] Grenoble Institut des Neurosciences
22 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
23 IP - Institut Pascal
24 CHU Clermont-Ferrand
25 NEURO - Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481)
26 Inserm CIC 1431 - Centre d'Investigation Clinique de Besançon
27 GHU Paris Psychiatrie et Neurosciences
28 HUSLS-LRB-FW - Département de Psychiatrie et de Médecine Addictologique [AP-HP HU Saint-Louis, Lariboisière, Fernand Widal]
M. Leboyer
  • Function : Author
E. Haffen
  • Function : Author
P. Llorca
  • Function : Author
V. Barteau
  • Function : Author
S. Bensalem
  • Function : Author
O. Godin
  • Function : Author
H. Laouamri
  • Function : Author
K. Souryis
  • Function : Author
S. Hotier
  • Function : Author
A. Pelletier
  • Function : Author
N. Drancourt
J. Sanchez
  • Function : Author
E. Saliou
  • Function : Author
C. Hebbache
  • Function : Author
J. Petrucci
  • Function : Author
L. Willaume
  • Function : Author
E. Bourdin
  • Function : Author
F. Bellivier
  • Function : Author
B. Etain
  • Function : Author
V. Hennion
  • Function : Author
E. Marlinge
  • Function : Author
P. Lebard
  • Function : Author
B. Antoniol
  • Function : Author
A. Desage
  • Function : Author
S. Gard
  • Function : Author
A. Jutant
  • Function : Author
K. Mbailara
  • Function : Author
I. Minois
  • Function : Author
L. Zanouy
  • Function : Author
C. Abettan
  • Function : Author
L. Bardin
  • Function : Author
A. Cazals
  • Function : Author
P. Courtet
  • Function : Author
B. Deffinis
  • Function : Author
D. Ducasse
  • Function : Author
M. Gachet
  • Function : Author
A. Henrion
  • Function : Author
E. Martinerie
  • Function : Author
F. Molière
  • Function : Author
B. Noisette
  • Function : Author
E. Olié
  • Function : Author
G. Tarquini
  • Function : Author
J. Azorin
  • Function : Author
R. Belzeaux
  • Function : Author
N. Correard
  • Function : Author
J. Consoloni
  • Function : Author
F. Groppi
  • Function : Author
L. Lescalier
  • Function : Author
J. Montant
  • Function : Author
M. Rebattu
  • Function : Author
N. Viglianese
  • Function : Author
R. Cohen
  • Function : Author
J. Kahn
  • Function : Author
M. Milazzo
  • Function : Author
O. Wajsbrot-Elgrabli
  • Function : Author
T. Bougerol
  • Function : Author
B. Fredembach
  • Function : Author
Q. Denoual
  • Function : Author
A. Bertrand
  • Function : Author
A. Pouchon
  • Function : Author
M. Polosan
  • Function : Author
L. Brehon
  • Function : Author
G. Bony
  • Function : Author
L. Durand
  • Function : Author
V. Feuga
  • Function : Author
N. Kayser
  • Function : Author
C. Passerieux
  • Function : Author
P. Roux
  • Function : Author
V. Aubin
  • Function : Author
I. Cussac
  • Function : Author
M. Dupont
  • Function : Author
J. Loftus
  • Function : Author
I. Medecin
  • Function : Author
C. Dubertret
  • Function : Author
N. Mazer
  • Function : Author
C. Portalier
  • Function : Author
C. Scognamiglio
  • Function : Author
A. Bing
  • Function : Author
P. Laurent
  • Function : Author
C. Beal
  • Function : Author
O. Blanc
  • Function : Author
T. Bonnet
  • Function : Author
D. Lacelle
  • Function : Author
P. Llorca
  • Function : Author
M. Mennetrier
  • Function : Author
L. Samalin
  • Function : Author
M. Vayssié
  • Function : Author

Abstract

Bipolar disorder (BD) has been associated with premature cellular aging with shortened telomere length (TL) as compared to the general population. We recently identified a subgroup of young individuals with prematurely shortened TL. The aims of the present study were to replicate this observation in a larger sample and analyze the expression levels of genes associated with age or TL in a subsample of these individuals. TL was measured on peripheral blood DNA using quantitative polymerase chain reaction in a sample of 542 individuals with BD and clustering analyses were performed. Gene expression level of 29 genes, associated with aging or with telomere maintenance, was analyzed in RNA samples from a subsample of 129 individuals. Clustering analyses identified a group of young individuals (mean age 29.64 years), with shorter TL. None of the tested clinical variables were significantly associated with this subgroup. Gene expression level analyses showed significant downregulation of MYC, POT1, and CD27 in the prematurely aged young individuals compared to the young individuals with longer TL. After adjustment only POT1 remained significantly differentially expressed between the two groups of young individuals. This study confirms the existence of a subgroup of young individuals with BD with shortened TL. The observed decrease of POT1 expression level suggests a newly described cellular mechanism in individuals with BD, that may contribute to telomere shortening.

Dates and versions

hal-04492634 , version 1 (06-03-2024)

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Luana Spano, Cynthia Marie-Claire, Ophélia Godin, Apolline Lebras, Cindie Courtin, et al.. Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1. Translational Psychiatry, 2024, 14 (1), pp.131. ⟨10.1038/s41398-024-02824-z⟩. ⟨hal-04492634⟩
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