Synthesis of Sydnonimines from Sydnones and their use for bioorthogonal release of isocyanates in cells
Résumé
In this article, we report the synthesis of sydnonimines from
sydnones and their use as dipoles for fast click-and-release
reactions. The process relies on nucleophilic aromatic
substitution of aliphatic and aromatic amines with triflated
sydnones. This new methodology allowed the preparation of
functionalised sydnonimines probes otherwise difficult to
prepare. Those probes were then used to release a drug and a
fluorescent aromatic isocyanate inside living cells
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| Licence |
Domaine public
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