Relevance of Tacrolimus Trough Concentration and Hepatitis E virus Genetic Changes in Kidney Transplant Recipients With Chronic Hepatitis E - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Kidney International Reports Année : 2024

Relevance of Tacrolimus Trough Concentration and Hepatitis E virus Genetic Changes in Kidney Transplant Recipients With Chronic Hepatitis E

Résumé

Introduction: Hepatitis E virus (HEV) can cause chronic infection ($3 months) and cirrhosis in immunocompromised patients, especially kidney transplant recipients. Low alanine aminotransferase (ALT) levels and high HEV intrahost diversity have previously been associated with evolution toward chronicity in these patients. We hypothesized that additional clinical and viral factors could be associated with the risk of chronic HEV infection. Methods: We investigated a series of 27 kidney transplant recipients with HEV infection, including 20 patients with chronic hepatitis E. Results: High tacrolimus trough concentration at diagnosis was the most relevant marker associated with chronic hepatitis E (9.2 vs. 6.4 ng/ml, P ¼ 0.04). Most HEV genetic changes selected during HEV infection were compartmentalized between plasma and feces. Conclusion: This compartmentalization highlights the diversity and complexity of HEV replication compartments. Tacrolimus trough concentration at diagnosis of HEV infection could allow an early identification of patients at high risk of chronic hepatitis E and guide treatment initiation.
Fichier principal
Vignette du fichier
León-Janampa et al. - 2024 - Relevance of Tacrolimus Trough Concentration and H.pdf (1.42 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-04491246 , version 1 (05-03-2024)

Licence

Identifiants

Citer

Nancy León-Janampa, Natacha Boennec, Olivier Le Tilly, Simon Ereh, Gabriel Herbet, et al.. Relevance of Tacrolimus Trough Concentration and Hepatitis E virus Genetic Changes in Kidney Transplant Recipients With Chronic Hepatitis E. Kidney International Reports, 2024, ⟨10.1016/j.ekir.2024.01.054⟩. ⟨hal-04491246⟩

Collections

INSERM UNIV-TOURS
3 Consultations
1 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More