Human cortex development is shaped by molecular and cellular brain systems
Leon Lotter
(1, 2)
,
Amin Saberi
(2, 1)
,
Justine Hansen
(3)
,
Bratislav Misic
(3)
,
Casey Paquola
(4)
,
Gareth Barker
(5)
,
Arun Bokde
(6)
,
Sylvane Desrivières
(5)
,
Herta Flor
(7)
,
Antoine Grigis
(8)
,
Hugh Garavan
(9)
,
Penny Gowland
(10)
,
Andreas Heinz
(11)
,
Rüdiger Brühl
(12)
,
Jean-Luc Martinot
(13, 14)
,
Marie-Laure Paillère
(13, 14)
,
Eric Artiges
(13, 14)
,
Dimitri Papadopoulos Orfanos
(8)
,
Tomáš Paus
(15)
,
Luise Poustka
(16)
,
Sarah Hohmann
(17)
,
Juliane Fröhner
(18)
,
Michael Smolka
(18)
,
Nilakshi Vaidya
,
Henrik Walter
(19)
,
Robert Whelan
(6)
,
Gunter Schumann
(11)
,
Frauke Nees
(7, 20)
,
Tobias Banaschewski
(7)
,
Simon Eickhoff
(1)
,
Juergen Dukart
(1, 4)
1
Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
2 IMPNSC - Max Planck Institute for Human Cognitive and Brain Sciences [Leipzig]
3 McGill University = Université McGill [Montréal, Canada]
4 Jülich Research Centre
5 King‘s College London
6 Trinity College Dublin
7 Heidelberg University Hospital [Heidelberg]
8 NEUROSPIN - Service NEUROSPIN
9 University of Vermont [Burlington]
10 UON - University of Nottingham, UK
11 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
12 Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig]
13 CB - CB - Centre Borelli - UMR 9010
14 ERL Inserm U1299 - Trajectoires développementales en psychiatrie : mesures et modélisations
15 UQAM - Université du Québec à Montréal = University of Québec in Montréal
16 UMG - University Medical Center Göttingen
17 Universität Heidelberg [Heidelberg] = Heidelberg University
18 TU Dresden - Technische Universität Dresden = Dresden University of Technology
19 Freie Universität Berlin
20 UKSH - University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein
2 IMPNSC - Max Planck Institute for Human Cognitive and Brain Sciences [Leipzig]
3 McGill University = Université McGill [Montréal, Canada]
4 Jülich Research Centre
5 King‘s College London
6 Trinity College Dublin
7 Heidelberg University Hospital [Heidelberg]
8 NEUROSPIN - Service NEUROSPIN
9 University of Vermont [Burlington]
10 UON - University of Nottingham, UK
11 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
12 Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig]
13 CB - CB - Centre Borelli - UMR 9010
14 ERL Inserm U1299 - Trajectoires développementales en psychiatrie : mesures et modélisations
15 UQAM - Université du Québec à Montréal = University of Québec in Montréal
16 UMG - University Medical Center Göttingen
17 Universität Heidelberg [Heidelberg] = Heidelberg University
18 TU Dresden - Technische Universität Dresden = Dresden University of Technology
19 Freie Universität Berlin
20 UKSH - University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein
Leon Lotter
- Fonction : Auteur
- PersonId : 1257783
- ORCID : 0000-0002-2337-6073
Justine Hansen
- Fonction : Auteur
- PersonId : 1355433
- ORCID : 0000-0003-3142-7480
Bratislav Misic
- Fonction : Auteur
- PersonId : 798669
- ORCID : 0000-0003-0307-2862
Casey Paquola
- Fonction : Auteur
- PersonId : 1316807
- ORCID : 0000-0002-0190-4103
Michael Smolka
- Fonction : Auteur
- PersonId : 1302950
- ORCID : 0000-0001-5398-5569
Nilakshi Vaidya
- Fonction : Auteur
Frauke Nees
- Fonction : Auteur
- PersonId : 1302951
- ORCID : 0000-0002-7796-8234
Tobias Banaschewski
- Fonction : Auteur
- PersonId : 763392
- ORCID : 0000-0003-4595-1144
Simon Eickhoff
- Fonction : Auteur
- PersonId : 1355434
- ORCID : 0000-0001-6363-2759
Juergen Dukart
- Fonction : Auteur
- PersonId : 1355435
- ORCID : 0000-0003-0492-5644
Résumé
Abstract Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking brain development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cerebral cortex development unfolds along patterns of molecular and cellular brain organization, traceable from population-level to individual developmental trajectories. During childhood and adolescence, cortex-wide spatial distributions of dopaminergic receptors, inhibitory neurons, glial cell populations, and brain-metabolic features explain up to 50% of variance associated with regional cortical thickness trajectories. Adult cortical change patterns are best explained by cholinergic and glutamatergic neurotransmission. These relationships are supported by developmental gene expression trajectories and translate to longitudinal data from over 8,000 adolescents, explaining up to 59% of developmental change at population- and 18% at single-subject level. Integrating multilevel brain atlases with normative modeling and population neuroimaging provides a biologically meaningful path to understand typical and atypical brain development in living humans.