Differential associations of adolescent versus young adult cannabis initiation with longitudinal brain change and behavior - Archive ouverte HAL
Article Dans Une Revue Molecular Psychiatry Année : 2023

Differential associations of adolescent versus young adult cannabis initiation with longitudinal brain change and behavior

Matthew Albaugh
University of Vermont [Burlington]
Max Owens
University of Vermont [Burlington]
Anthony Juliano
  • Fonction : Auteur
University of Vermont [Burlington]
Jonatan Ottino-Gonzalez
  • Fonction : Auteur
University of Vermont [Burlington]
Renata Cupertino
University of Vermont [Burlington]
Zhipeng Cao
  • Fonction : Auteur
University of Vermont [Burlington]
Scott Mackey
University of Vermont [Burlington]
Claude Lepage
  • Fonction : Auteur
McGill University = Université McGill [Montréal, Canada]
Pierre Rioux
  • Fonction : Auteur
McGill University = Université McGill [Montréal, Canada]
Alan Evans
  • Fonction : Auteur
McGill University = Université McGill [Montréal, Canada]
Tobias Banaschewski
Central Institute of Mental Health [Mannheim]
Arun Bokde
Trinity College Dublin
Patricia Conrod
Université du Québec à Montréal = University of Québec in Montréal
Sylvane Desrivières
King‘s College London
Herta Flor
Central Institute of Mental Health [Mannheim]
Antoine Grigis
  • Fonction : Auteur
Service NEUROSPIN
Penny Gowland
University of Nottingham, UK
Andreas Heinz
Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin
Bernd Ittermann
  • Fonction : Auteur
Jean-Luc Martinot
CB - Centre Borelli - UMR 9010
Trajectoires développementales en psychiatrie : mesures et modélisations
Marie-Laure Paillère Martinot
CB - Centre Borelli - UMR 9010
Trajectoires développementales en psychiatrie : mesures et modélisations
Eric Artiges
CB - Centre Borelli - UMR 9010
Trajectoires développementales en psychiatrie : mesures et modélisations
Frauke Nees
Dimitri Papadopoulos Orfanos
Service NEUROSPIN
CV
Tomáš Paus
Luise Poustka
  • Fonction : Auteur
Sabina Millenet
  • Fonction : Auteur
Juliane Fröhner
Michael Smolka
Henrik Walter
Robert Whelan
Gunter Schumann
Alexandra Potter
  • Fonction : Auteur
Hugh Garavan
  • Fonction : Auteur

Résumé

Leveraging ~10 years of prospective longitudinal data on 704 participants, we examined the effects of adolescent versus young adult cannabis initiation on MRI-assessed cortical thickness development and behavior. Data were obtained from the IMAGEN study conducted across eight European sites. We identified IMAGEN participants who reported being cannabis-naïve at baseline and had data available at baseline, 5-year, and 9-year follow-up visits. Cannabis use was assessed with the European School Survey Project on Alcohol and Drugs. T1-weighted MR images were processed through the CIVET pipeline. Cannabis initiation occurring during adolescence (14-19 years) and young adulthood (19-22 years) was associated with differing patterns of longitudinal cortical thickness change. Associations between adolescent cannabis initiation and cortical thickness change were observed primarily in dorso- and ventrolateral portions of the prefrontal cortex. In contrast, cannabis initiation occurring between 19 and 22 years of age was associated with thickness change in temporal and cortical midline areas. Follow-up analysis revealed that longitudinal brain change related to adolescent initiation persisted into young adulthood and partially mediated the association between adolescent cannabis use and past-month cocaine, ecstasy, and cannabis use at age 22. Extent of cannabis initiation during young adulthood (from 19 to 22 years) had an indirect effect on psychotic symptoms at age 22 through thickness change in temporal areas. Results suggest that developmental timing of cannabis exposure may have a marked effect on neuroanatomical correlates of cannabis use as well as associated behavioral sequelae. Critically, this work provides a foundation for neurodevelopmentally informed models of cannabis exposure in humans.

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Sciences du Vivant [q-bio]

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https://hal.science/hal-04471245

Soumis le : mercredi 21 février 2024-15:21:15

Dernière modification le : mercredi 30 octobre 2024-18:16:57

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hal-04471245 , version 1 (21-02-2024)

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Matthew Albaugh, Max Owens, Anthony Juliano, Jonatan Ottino-Gonzalez, Renata Cupertino, et al.. Differential associations of adolescent versus young adult cannabis initiation with longitudinal brain change and behavior. Molecular Psychiatry, 2023, ⟨10.1038/s41380-023-02148-2⟩. ⟨hal-04471245⟩

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