We present the second release of the Meta-catalogue of X-Ray detected Clusters of galaxies (hereafter MCXC-II). The MCXC-II has been compiled from publicly available ROSAT All Sky Survey-based (NORAS, REFLEX, BCS, SGP, NEP, MACS, CIZA, RXGCC) and serendipitous (160SD, 400SD, SHARC, WARPS, and EMSS) cluster catalogues. Redshifts were systematically checked and updated if necessary, and additional redshift information (type and origin) added. The X-ray data were standardised to an overdensity of 500 using a new procedure based on the use of the original flux and aperture measurements available in the input catalogues. MCXC-II contains 2221 entries, essentially completing the census of ROSAT cluster detections by including objects from the REFLEX-II and RXGCC surveys, in addition to providing a complete and fully-homogenised sub-catalogue of all published MACS clusters. Duplicate entries from overlaps between the survey areas of the individual input catalogues were carefully handled. For each cluster the MCXC-II provides three identifiers, a redshift, coordinates, membership in the original catalogue, and standardised [0.1-2.4] keV band luminosity $L_{500}$, total mass $M_{500}$, and radius $R_{500}$. Uncertainties on $L_{500}$ were computed from the flux errors in the original catalogues. MCXC-II additionally furnishes information on overlaps between the input catalogues, gives the luminosity and its uncertainty when measurements from different surveys are available, and provides notes on individual objects.