CSF β-amyloid is not a prognostic marker in multiple sclerosis patients - Archive ouverte HAL
Article Dans Une Revue Multiple Sclerosis and Related Disorders Année : 2022

CSF β-amyloid is not a prognostic marker in multiple sclerosis patients

Résumé

Background: Multiple sclerosis (MS) is the most common chronic inflammatory, demyelinating disorder. Given its variable prognosis, the identification of new prognostic biomarkers is needed. Objectives: The aims of our study were to assess the prognostic values of CSF β-amyloid-42 (Aβ42) and β-amyloid40 (Aβ40) levels in MS patients. Methods: Eighty-nine (55 RRMS, 34 PPMS) patients with a recent diagnosis and 27 controls were included in this single-centre retrospective study. Clinical, MRI and CSF data have been collected and were analysed to evaluate the potential value of CSF Aβ42 and Aβ40 levels as MS biomarkers. Results: CSF Aβ levels as well as Aβ42/Aβ40 ratio were identical in MS patients and controls. Although CSF Aβ42 and Aβ40 levels were higher in PPMS than in RRMS and in patients with higher EDSS, a multivariate analysis including age and EDSS demonstrated that only age of patients was associated with CSF amyloid levels. Additionally, 55 RRMS patients were followed for 3 years. We found no association between baseline amyloid levels and 3-year disability. Conclusion: Our data do not support an association between CSF amyloid levels and MS status and disease severity. We suggest that CSF amyloid levels are not a prognostic biomarker in recently diagnosed RRMS.

Dates et versions

hal-04467644 , version 1 (20-02-2024)

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Justine Petitfour, Xavier Ayrignac, Nelly Ginestet, Pauline Prin, Clarisse Carra-Dallière, et al.. CSF β-amyloid is not a prognostic marker in multiple sclerosis patients. Multiple Sclerosis and Related Disorders, 2022, 68, pp.104096. ⟨10.1016/j.msard.2022.104096⟩. ⟨hal-04467644⟩
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