Simple hybrid polymeric nanostructures encapsulating macro-cyclic Gd/Eu based complexes: luminescence properties and application as MRI contrast agent - Archive ouverte HAL
Article Dans Une Revue Nanoscale Année : 2024

Simple hybrid polymeric nanostructures encapsulating macro-cyclic Gd/Eu based complexes: luminescence properties and application as MRI contrast agent

Résumé

Lanthanide-based macrocycles are successfully incorporated into hybrid polyionic complexes, formed by adding a mixture of zirconium ions to a solution of a double-hydrophilic block copolymer. The resulting nanoobjects with an average radius of approximately 10–15 nm present good colloidal and chemical stability in physiological media even in the presence of competing ions such as phosphate or calcium ions. The final optical and magnetic properties of these objects benefit from both their colloidal nature and the specific properties of the complexes. Hence these new nanocarriers exhibit enhanced T1 MRI contrast, when administered intravenously to mice. .
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Dates et versions

hal-04465688 , version 1 (04-04-2024)

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Marjorie Yon, Lucie Esmangard, Morgane Enel, Franck Desmoulin, Carine Pestourie, et al.. Simple hybrid polymeric nanostructures encapsulating macro-cyclic Gd/Eu based complexes: luminescence properties and application as MRI contrast agent. Nanoscale, 2024, 16 (7), pp.3729-3737. ⟨10.1039/d3nr06162k⟩. ⟨hal-04465688⟩
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