We define and study the multidimensional Appell polynomials associated with theta functions. For the trivial theta functions, we obtain the various well‐known Appell polynomials. Many other interesting examples are given. To push our study, by Mellin transform, we introduce and investigate the multidimensional zeta functions associated with thetas functions and prove that the multidimensional Appell polynomials are special values at the nonpositive integers of these zeta functions. Using zeta functions techniques, among others, we prove an induction formula for multidimensional Appell polynomials. The last part of this paper is devoted to spectral zeta functions and its generalization associated with Laplacians on compact Riemannian manifolds. From this generalization, we construct new Appell polynomials associated with Riemannan manifolds of finite dimensions.