<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04462826</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-23T04:53:50+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">A druggable secretory protein maturase of Toxoplasma essential for invasion and egress</title>
            <author role="aut">
              <persName>
                <forename type="first">Sunil Kumar</forename>
                <surname>Dogga</surname>
              </persName>
              <idno type="idhal" notation="numeric">1353536</idno>
              <idno type="halauthorid" notation="string">2095285-1353536</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9158-9612</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Budhaditya</forename>
                <surname>Mukherjee</surname>
              </persName>
              <idno type="idhal" notation="numeric">1353537</idno>
              <idno type="halauthorid" notation="string">3058640-1353537</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1058-3620</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Damien</forename>
                <surname>Jacot</surname>
              </persName>
              <idno type="halauthorid">886435-0</idno>
              <affiliation ref="#struct-154620"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Tobias</forename>
                <surname>Kockmann</surname>
              </persName>
              <idno type="halauthorid">3058641-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luca</forename>
                <surname>Molino</surname>
              </persName>
              <idno type="halauthorid">3058642-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre-Mehdi</forename>
                <surname>Hammoudi</surname>
              </persName>
              <idno type="halauthorid">1556598-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ruben</forename>
                <forename type="middle">Christiaan</forename>
                <surname>Hartkoorn</surname>
              </persName>
              <email type="md5">39f3452ae68f5157d030997798e08505</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">ruben-hartkoorn</idno>
              <idno type="idhal" notation="numeric">1137689</idno>
              <idno type="halauthorid" notation="string">3018160-1137689</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/U-2698-2017</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/U-2698-2017</idno>
              <affiliation ref="#struct-106189"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Adrian</forename>
                <surname>Hehl</surname>
              </persName>
              <idno type="halauthorid">3058643-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dominique</forename>
                <surname>Soldati-Favre</surname>
              </persName>
              <email type="md5">0d7438c04384f381735db932b8f300b8</email>
              <email type="domain">unige.ch</email>
              <idno type="idhal" notation="numeric">941016</idno>
              <idno type="halauthorid" notation="string">709086-941016</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4156-2109</idno>
              <idno type="IDREF">https://www.idref.fr/119646404</idno>
              <affiliation ref="#struct-154620"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Ruben</forename>
                <surname>Hartkoorn</surname>
              </persName>
              <email type="md5">39f3452ae68f5157d030997798e08505</email>
              <email type="domain">inserm.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-02-16 16:33:25</date>
              <date type="whenModified">2025-05-13 11:30:26</date>
              <date type="whenReleased">2024-02-16 16:33:25</date>
              <date type="whenProduced">2017-09-12</date>
              <ref type="externalLink" target="https://doi.org/10.7554/elife.27480"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="611112">
                <persName>
                  <forename>Ruben</forename>
                  <surname>Hartkoorn</surname>
                </persName>
                <email type="md5">39f3452ae68f5157d030997798e08505</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04462826</idno>
            <idno type="halUri">https://hal.science/hal-04462826</idno>
            <idno type="halBibtex">dogga:hal-04462826</idno>
            <idno type="halRefHtml">&lt;i&gt;eLife&lt;/i&gt;, 2017, 6, &lt;a target="_blank" href="https://dx.doi.org/10.7554/eLife.27480"&gt;&amp;#x27E8;10.7554/eLife.27480&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">eLife, 2017, 6, &amp;#x27E8;10.7554/eLife.27480&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="RIIP">Pasteur Network</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="RIIP_LILLE" corresp="RIIP">Institut Pasteur de Lille</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="CIIL">Centre d'Infection et d'Immunité de Lille</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">A druggable secretory protein maturase of Toxoplasma essential for invasion and egress</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Sunil Kumar</forename>
                    <surname>Dogga</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1353536</idno>
                  <idno type="halauthorid" notation="string">2095285-1353536</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9158-9612</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Budhaditya</forename>
                    <surname>Mukherjee</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1353537</idno>
                  <idno type="halauthorid" notation="string">3058640-1353537</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1058-3620</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Damien</forename>
                    <surname>Jacot</surname>
                  </persName>
                  <idno type="halauthorid">886435-0</idno>
                  <affiliation ref="#struct-154620"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Tobias</forename>
                    <surname>Kockmann</surname>
                  </persName>
                  <idno type="halauthorid">3058641-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luca</forename>
                    <surname>Molino</surname>
                  </persName>
                  <idno type="halauthorid">3058642-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre-Mehdi</forename>
                    <surname>Hammoudi</surname>
                  </persName>
                  <idno type="halauthorid">1556598-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ruben</forename>
                    <forename type="middle">Christiaan</forename>
                    <surname>Hartkoorn</surname>
                  </persName>
                  <email type="md5">39f3452ae68f5157d030997798e08505</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">ruben-hartkoorn</idno>
                  <idno type="idhal" notation="numeric">1137689</idno>
                  <idno type="halauthorid" notation="string">3018160-1137689</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/U-2698-2017</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/U-2698-2017</idno>
                  <affiliation ref="#struct-106189"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Adrian</forename>
                    <surname>Hehl</surname>
                  </persName>
                  <idno type="halauthorid">3058643-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dominique</forename>
                    <surname>Soldati-Favre</surname>
                  </persName>
                  <email type="md5">0d7438c04384f381735db932b8f300b8</email>
                  <email type="domain">unige.ch</email>
                  <idno type="idhal" notation="numeric">941016</idno>
                  <idno type="halauthorid" notation="string">709086-941016</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4156-2109</idno>
                  <idno type="IDREF">https://www.idref.fr/119646404</idno>
                  <affiliation ref="#struct-154620"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">90086</idno>
                <idno type="eissn">2050-084X</idno>
                <title level="j">eLife</title>
                <imprint>
                  <publisher>eLife Sciences Publication</publisher>
                  <biblScope unit="volume">6</biblScope>
                  <date type="datePub">2017-09-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.7554/eLife.27480</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Micronemes and rhoptries are specialized secretory organelles that deploy their contents at the apical tip of apicomplexan parasites in a regulated manner. The secretory proteins participate in motility, invasion, and egress and are subjected to proteolytic maturation prior to organellar storage and discharge. Here we establish that Toxoplasma gondii aspartyl protease 3 (ASP3) resides in the endosomal-like compartment and is crucially associated to rhoptry discharge during invasion and to host cell plasma membrane lysis during egress. A comparison of the N-terminome, by terminal amine isotopic labelling of substrates between wild type and ASP3 depleted parasites identified microneme and rhoptry proteins as repertoire of ASP3 substrates. The role of ASP3 as a maturase for previously described and newly identified secretory proteins is confirmed in vivo and in vitro. An antimalarial compound based on a hydroxyethylamine scaffold interrupts the lytic cycle of T. gondii at submicromolar concentration by targeting ASP3.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-154620" status="VALID">
          <idno type="ROR">https://ror.org/01swzsf04</idno>
          <orgName>Université de Genève = University of Geneva</orgName>
          <orgName type="acronym">UNIGE</orgName>
          <date type="start">1559-01-01</date>
          <desc>
            <address>
              <addrLine>24 rue du Général-Dufour CH - 1211 Genève 4Suisse</addrLine>
              <country key="CH"/>
            </address>
            <ref type="url">http://www.unige.ch/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-106189" status="VALID">
          <idno type="IdRef">190712678</idno>
          <idno type="ISNI">0000 0004 0386 3856</idno>
          <idno type="RNSR">201019101Y</idno>
          <idno type="ROR">https://ror.org/00dyt5s15</idno>
          <idno type="Wikidata">Q16507419</idno>
          <orgName>Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204</orgName>
          <orgName type="acronym">CIIL</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019 - BP 245</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ciil.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR8204" active="#struct-300166" type="direct"/>
            <relation active="#struct-301247" type="indirect"/>
            <relation name="U1019" active="#struct-303623" type="direct"/>
            <relation name="UMR9017" active="#struct-374570" type="direct"/>
            <relation name="U1019" active="#struct-425779" type="direct"/>
            <relation name="UMR9017" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300166" status="VALID">
          <idno type="ROR">https://ror.org/05k9skc85</idno>
          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>
            <address>
              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301247" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301247" status="VALID">
          <orgName>Pasteur Network (Réseau International des Instituts Pasteur)</orgName>
          <desc>
            <address>
              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-network.org/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-374570" status="VALID">
          <idno type="IdRef">223446556</idno>
          <idno type="ISNI">0000 0001 2242 6780</idno>
          <idno type="ROR">https://ror.org/02kzqn938</idno>
          <idno type="Wikidata">Q3551621</idno>
          <orgName>Université de Lille</orgName>
          <desc>
            <address>
              <addrLine>EPE Université de Lille. -- 42 rue Paul Duez, 59000 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-425779" status="VALID">
          <idno type="IdRef">034424636</idno>
          <idno type="ISNI">0000000404718845</idno>
          <idno type="ROR">https://ror.org/02ppyfa04</idno>
          <idno type="Wikidata">Q2945741</idno>
          <orgName>Centre Hospitalier Régional Universitaire [CHU Lille]</orgName>
          <orgName type="acronym">CHRU Lille</orgName>
          <desc>
            <address>
              <addrLine>CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chru-lille.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>