ANTIBODIES, FRAGMENTS OR DERIVATIVES SPECIFICALLY BINDING TO A PROTEIN ANTIGEN CAPABLE OF BINDING TO NUCLEIC ACIDS, AND USES OF SAME - Archive ouverte HAL Accéder directement au contenu
Brevet Année : 2021

ANTIBODIES, FRAGMENTS OR DERIVATIVES SPECIFICALLY BINDING TO A PROTEIN ANTIGEN CAPABLE OF BINDING TO NUCLEIC ACIDS, AND USES OF SAME

Résumé

The present invention relates to a specific antibody of a protein antigen capable of binding to nucleic acids, or a fragment or a derivative of such an antibody binding to the antigen, for use as a drug, in particular in the treatment or prevention of inflammation, due especially to an infection or an autoimmune disease, characterized in that the antibody, fragment or derivative has a reduced capacity to bind to the FcγRIIA receptor and/or an increased capacity to bind to the FcγRIIB receptor. The antibody, fragment or derivative is preferably without an Fc domain, or with a modified Fc domain with a reduced capacity to bind to FcγRIIA and optionally FcγRIIA (or even a reduced capacity to bind to all FcγR), and/or with a modified Fc domain with an increased capacity to bind to FcγRIIB.
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Dates et versions

hal-04459218 , version 1 (15-02-2024)

Identifiants

  • HAL Id : hal-04459218 , version 1

Citer

Oscar Henrique Pereira Ramos, Michel Leonetti, Stéphanie Simon, Gwenaëlle Le Roux, Nathalie Morel. ANTIBODIES, FRAGMENTS OR DERIVATIVES SPECIFICALLY BINDING TO A PROTEIN ANTIGEN CAPABLE OF BINDING TO NUCLEIC ACIDS, AND USES OF SAME. France, Patent n° : WO2022180342A1. 2021. ⟨hal-04459218⟩
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