A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation
Résumé
Key Points The fusion between FVIII and anti-VWF nanobodies increases affinity for VWF 25-fold without compromising FVIII activity. Stabilized VWF binding results in a twofold enhanced circulatory survival of FVIII and reduced anti-FVIII antibody formation.
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Muczynski et al FVIII-nanobody fusion protein .pdf (1.97 Mo)
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