Cannabidiol in sport : ergogenic or else?
Résumé
In the sports domain, cannabis is prohibited by the World Anti-Doping Agency (WADA) across all sports in competition since 2004. The few studies on physical exercise and cannabis focused on the main compound i.e. Δ9-tetrahydrocannabinol. Cannabidiol (CBD) is another well-known phytocannabinoid present in dried or heated preparations of cannabis. Unlike Δ9-tetrahydrocannabinol, CBD is non-intoxicating but exhibits pharmacological properties that are interesting for medical use. The worldwide regulatory status of CBD is complex and this compound is still a controlled substance in many countries. Interestingly, however, the World Anti-Doping Agency removed CBD from the list of prohibited substancesin or out of competition-since 2018. This recent decision by the WADA leaves the door open for CBD use by athletes. In the present opinion article we wish to expose the different CBD properties discovered in preclinical studies that could be further tested in the sport domain to ascertain its utility. Preclinical studies suggest that CBD could be useful to athletes due to its antiinflammatory, analgesic, anxiolytic, neuroprotective properties and its influence on the sleep-wake cycle. Unfortunately, almost no clinical data are available on CBD in the context of exercise, which makes its use in this context still premature.
Mots clés
Cannabinoid receptor 2 CBD
Cannabidiol CTE
Chronic traumatic encephalopathy DOMS
Delayed onset muscle soreness FAAH
fatty acid amide hydrolase GDNF
Glial cell line-derived neurotrophic factor NO
Nitric oxide NFT
Neurofibrillary tangles NGF
Nerve growth factor mTBI
Mild traumatic brain injury PGE 2
Prostaglandin E2 PPARγ
Peroxisome proliferator-activated receptor γ TRPV1
Transient receptor potential cation channel subfamily V member 1 WADA
World Anti-Doping Agency
2-arachidonylglycérol
5-HT 1A
Serotonin 1A receptor
Aβ
Beta amyloid
AEA
Anadamide
Δ9-THC
Delta 9-tetrahydrocannabinol
CB1
Cannabinoid receptor 1
CB2
Cannabinoid receptor 2
CBD
Cannabidiol
CTE
Chronic traumatic encephalopathy
DOMS
Delayed onset muscle soreness
FAAH
fatty acid amide hydrolase
GDNF
Glial cell line-derived neurotrophic factor
NO
Nitric oxide
NFT
Neurofibrillary tangles
NGF
Nerve growth factor
mTBI
Mild traumatic brain injury
PGE 2
Prostaglandin E2
PPARγ
Peroxisome proliferator-activated receptor γ
TRPV1
Transient receptor potential cation channel subfamily V member 1
WADA
Anxiolytic Cannabidiol Cannabis Doping Neuroprotective Sleep-wake cycle 2-AG
2-arachidonylglycérol 5-HT 1A
Serotonin 1A receptor Aβ
Beta amyloid AEA
Anadamide Δ9-THC
Delta 9-tetrahydrocannabinol CB1
Cannabinoid receptor 1 CB2
Domaines
Sciences du Vivant [q-bio]
Fichier principal
Gamelin et al. - 2020 - Cannabidiol in sport Ergogenic or else.pdf (249.12 Ko)
Télécharger le fichier
| Origine | Fichiers éditeurs autorisés sur une archive ouverte |
|---|