The antiproliferative activity of Varronia dardani (Taroda) J.S. Mill. roots against human melanoma cells and the isolation of a new hydroanthraquinone - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Phytochemistry Letters Année : 2024

The antiproliferative activity of Varronia dardani (Taroda) J.S. Mill. roots against human melanoma cells and the isolation of a new hydroanthraquinone

Résumé

The Caatinga is a unique Brazilian semi-arid biome in the northeast of the country, containing endemic plant species. Among these, Cordiaceae are traditionally used by local communities for the treatment of various diseases such as gastric pain, menstrual colic and arthritis. In this work, the antiproliferative activity of the species Varronia dardani was evaluated in chemoresistant human melanoma cells. The ethanolic extract of V.dardani root exerted high antiproliferative activity in A2058 cells and was selected for further phytochemical characterization and bioguided purification of antimelanoma compounds. The isopropanol fraction was the most active and contained a novel hydroanthraquinone which was isolated, characterized and named vardanone. This molecule is the first hydroanthraquinone reported in V. dardani and UPLC-MS/MS analysis revealed that it was composed of a mixture of isomers. When tested in melanoma cells, vardanone didn't induce the inhibition of A2058 cell growth, indicating that the fraction's antimelanoma activity is attributable to other molecules which will be further characterized. This study is the first to demonstrate the presence of a hydroanthraquinone in V. dardani and paves the way for the identification of new antimelanoma phytochemicals in this species.
Fichier sous embargo
Fichier sous embargo
0 1 19
Année Mois Jours
Avant la publication
samedi 15 juin 2024
Fichier sous embargo
samedi 15 juin 2024
Connectez-vous pour demander l'accès au fichier

Dates et versions

hal-04447380 , version 1 (08-02-2024)

Identifiants

Citer

Carlos Arthur Gouveia Veloso, César Augusto Gonçalves Dantas, Raimundo Gonçalves de Oliveira Júnior, Vicente Carlos de Oliveira Costa, Luiz Antonio Miranda de Souza Duarte-Filho, et al.. The antiproliferative activity of Varronia dardani (Taroda) J.S. Mill. roots against human melanoma cells and the isolation of a new hydroanthraquinone. Phytochemistry Letters, 2024, 59, pp.45-52. ⟨10.1016/j.phytol.2023.12.004⟩. ⟨hal-04447380⟩
13 Consultations
2 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More