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Article Dans Une Revue AJP - Endocrinology and Metabolism Année : 2001

Energy nutrients modulate the splanchnic sequestration of dietary nitrogen in humans: a compartmental analysis

Résumé

We used a previously developed compartmental model to assess the postprandial distribution and metabolism of dietary nitrogen (N) in the splanchnic and peripheral areas after the ingestion of a single meal containing milk protein either alone (MP) or with additional sucrose (SMP) or fat (FMP). The addition of fat was predicted to enhance splanchnic dietary N anabolism only transiently, without significantly affecting the global kinetics of splanchnic retention and peripheral uptake. In contrast, the addition of sucrose, which induced hyperinsulinemia, was predicted to enhance dietary N retention and anabolism in the splanchnic bed, thus leading to reduced peripheral dietary amino acid availability and anabolism. The incorporation of dietary N into splanchnic proteins was thus predicted to reach 18, 24, and 35% of ingested N 8 h after MP, FMP, and SMP, respectively. Such a model provides insight into the dynamics of the system in the nonsteady postprandial state and constitutes a useful, explanatory tool to determine the region-specific utilization of dietary N under different nutritional conditions.
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Dates et versions

hal-04423915 , version 1 (31-01-2024)

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Hélène Fouillet, C. Gaudichon, F. Mariotti, C. Bos, J. Huneau, et al.. Energy nutrients modulate the splanchnic sequestration of dietary nitrogen in humans: a compartmental analysis. AJP - Endocrinology and Metabolism, 2001, 281 (2), pp. E248-E260. ⟨10.1152/ajpendo.2001.281.2.E248⟩. ⟨hal-04423915⟩
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