Peripheral and Splanchnic Metabolism of Dietary Nitrogen Are Differently Affected by the Protein Source in Humans as Assessed by Compartmental Modeling - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Nutrition Année : 2002

Peripheral and Splanchnic Metabolism of Dietary Nitrogen Are Differently Affected by the Protein Source in Humans as Assessed by Compartmental Modeling

Résumé

We used a previously developed compartmental model to assess the postprandial distribution and metabolism of dietary nitrogen (N) in the splanchnic and peripheral areas after the ingestion of a single mixed meal containing either 15 N-labeled milk or soy purified protein. Although the lower whole-body retention of dietary N from soy protein was measured experimentally, the splanchnic retention of dietary N was predicted by the model not to be affected by the protein source, and its incorporation into splanchnic proteins was predicted to reach ϳ35% of ingested N at 8 h after both meals. However, dietary N intestinal absorption and its appearance in splanchnic free amino acids were predicted to be more rapid from soy protein and were associated with a higher deamination, concomitant with a higher efficiency of incorporation of dietary N into proteins in the splanchnic bed. In contrast, soy protein was predicted to cause a reduction in peripheral dietary N uptake, as a consequence of both similar splanchnic retention and increased oxidation compared with milk protein. In addition, protein synthesis efficiency was reduced in the peripheral area after soy protein intake, leading to dietary N incorporation in peripheral proteins that fell from 26 to 19% of ingested N 8 h after milk and soy protein ingestion, respectively. Such a model thus enables a description of the processes involved in the differential metabolic utilization of dietary proteins and constitutes a valuable tool for further definition of the notion of protein quality during the period of protein gain.

Dates et versions

hal-04423904 , version 1 (31-01-2024)

Identifiants

Citer

Hélène Fouillet, François Mariotti, Claire C. Gaudichon, Cécile Bos, Daniel Tomé. Peripheral and Splanchnic Metabolism of Dietary Nitrogen Are Differently Affected by the Protein Source in Humans as Assessed by Compartmental Modeling. Journal of Nutrition, 2002, 132 (1), pp. 125-133. ⟨10.1093/jn/132.1.125⟩. ⟨hal-04423904⟩
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