We obtain additional Diophantine applications of the methods surrounding Darmon's program for the generalized Fermat equation developed in the first part of this series of papers. As a first application, we use a multi-Frey approach combining two Frey elliptic curves over totally real fields, a Frey hyperelliptic curve over $\mathbb{Q}$ due to Kraus, and ideas from the Darmon program to give a complete resolution of the generalized Fermat equation $$x^7 + y^7 = 3 z^n$$ for all integers $n \ge 2$. Moreover, we explain how the use of higher dimensional Frey abelian varieties allows a more efficient proof of this result due to additional structures that they afford, compared to using only Frey elliptic curves. As a second application, we use some of these additional structures that Frey abelian varieties possess to show that a full resolution of the generalized Fermat equation $x^7 + y^7 = z^n$ depends only on the Cartan case of Darmon's big image conjecture. In the process, we solve the previous equation for solutions $(a,b,c)$ such that $a$ and $b$ satisfy certain $2$ or $7$-adic conditions and all $n \ge 2$.