Episodes 20 and 21 of season 8 of ER, broadcast in 2002, feature the death of Dr. Mark Greene (played by Anthony Edwards). This death is first announced in episode 20 through a letter read in the hospital by Doctor John Carter (Noah Wyle), then shown in episode 21, in a flashback that takes place on the island of Hawaii. This article intends to show that the disappearance of this key character not only marks the true end of this flagship series of the 1990s, but also the beginning of a new television era with the arrival of LOST on ABC in 2004.