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Article Dans Une Revue Translational Psychiatry Année : 2023

Molecular mapping of a core transcriptional signature of microglia-specific genes in schizophrenia

Résumé

Besides playing a central role in neuroinflammation, microglia regulate synaptic development and is involved in plasticity. Converging lines of evidence suggest that these different processes play a critical role in schizophrenia. Furthermore, previous studies reported altered transcription of microglia genes in schizophrenia, while microglia itself seems to be involved in the etiopathology of the disease. However, the regional specificity of these brain transcriptional abnormalities remains unclear. Moreover, it is unknown whether brain and peripheral expression of microglia genes are related. Thus, we investigated the expression of a pre-registered list of 10 genes from a core signature of human microglia both at brain and peripheral levels. We included 9 independent Gene Expression Omnibus datasets (764 samples obtained from 266 individuals with schizophrenia and 237 healthy controls) from 8 different brain regions and 3 peripheral tissues. We report evidence of a widespread transcriptional alteration of microglia genes both in brain tissues (we observed a decreased expression in the cerebellum, associative striatum, hippocampus, and parietal cortex of individuals with schizophrenia compared with healthy controls) and whole blood (characterized by a mixed altered expression pattern). Our results suggest that brain underexpression of microglia genes may represent a candidate transcriptional signature for schizophrenia. Moreover, the dual brain-whole blood transcriptional alterations of microglia/macrophage genes identified support the model of schizophrenia as a whole-body disorder and lend weight to the use of blood samples as a potential source of biological peripheral biomarkers.
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Dates et versions

hal-04418118 , version 1 (25-01-2024)

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Anna Fiorito, Eric Fakra, Guillaume Sescousse, El Chérif Ibrahim, Romain Rey. Molecular mapping of a core transcriptional signature of microglia-specific genes in schizophrenia. Translational Psychiatry, 2023, 13 (1), pp.386. ⟨10.1038/s41398-023-02677-y⟩. ⟨hal-04418118⟩
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