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Article Dans Une Revue Pharmaceutics Année : 2023

Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease

Thomas Guiselin
  • Fonction : Auteur
Cédric Lecoutey
  • Fonction : Auteur
Patrick Dallemagne

Résumé

The multifactorial nature of some diseases, particularly neurodegenerative diseases such as Alzheimer’s disease, frequently requires the use of several drugs. These drug cocktails are not without drawbacks in terms of increased adverse effects, drug–drug interactions or low adherence to treatment. The use of pleiotropic drugs, which combine, within a single molecule, several activities directed against distinct therapeutic targets, makes it possible to overcome some of these problems. In addition, these pleiotropic drugs generally lead to the expression of a synergy of effects, sometimes greater than that observed with a combination of drugs. This article will review, through recent examples, the different kinds of pleiotropic drugs being studied or already present on the market of medicines, with a focus on the structural aspect of such drug design.

Domaines

Chimie

Dates et versions

hal-04414828 , version 1 (24-01-2024)

Identifiants

Citer

Thomas Guiselin, Cédric Lecoutey, Christophe Rochais, Patrick Dallemagne. Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease. Pharmaceutics, 2023, 15 (10), pp.2382. ⟨10.3390/pharmaceutics15102382⟩. ⟨hal-04414828⟩
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