Intracranial Aneurysm Treatment by New Bioactive Endoprosthesis
Résumé
Introduction: In this presentation we give an overview of modified surface coil technologies. We present potential perspectives to develop biologically optimized devices. We propose an innovative approach to optimize the healing of aneurysms by fucoidan-coated coils.
Method(s): We have conducted a feasibility study. Elastase induced aneurysms were created in 45 rabbits divided into two treatment groups. Embolization was performed with bare platinum coils or fucoidan covered coils. One month later control DSA was performed, aneurysm filling was measured by modified Raymond–Roy scale. Histological samples were collected and aneurysm healing and fibrosis were measured by quantifying mainly collagens on standard light microscope and multiphoton microscopy.
Result(s): No significant difference could be found at angiography. A significant difference was found with the presence of more collagen in the neck region of aneurysms treated with fucoidan covered coils versus bare platinum coils also histological index and collagen organization index differed significantly.
Conclusion(s): Our work presents a proof-of-concept study to demonstrate the feasibility and biological efficacy of treatment with coils coated with fucoidan. We have demonstrated the feasibility of grafting fucoidan.